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《Labeled Immunoassays and Clinical Medicine》 2017-11
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Detection and Analysis of Immunoglobulins,Complements and Autoantibody Levels in the Sera of Vitiligo Patients

LIU Cheng-gang;YANG Hui;LI Jian-biao;REN Qu;ZHU Mei-cai;Center of Clinical Laboratory,Air Force General Hospital;  
Objective Detection and analysis of the immunoglobulins IgG,IgA,IgM,complements C3,C4,antinuclear antibody( ANA),antibody against thyroid peroxidase( A-TPO) and antibody against thyroglobulin( A-TG) in the sera of vitiligo patients. Methods 168 cases of serum samples of vitiligo patients and 88 cases of normal samples from physical examination were collected,there were no statistical difference in the gender and the age distribution between the two groups. Rate scattering turbidimetric method was used to detect the immunoglobulins IgG,IgA,IgM,complements C3,C4 levels; ELISA method was used to detect the ANA levels,while A-TPO,A-TG levels were detected by using Electrochemilum inescence analysis method,and the results were analyzed by SPSS19. 0 statistical software. Results No statistical difference were found in levels of immunoglobulins IgG,IgA,IgM,complements C3,C4 between the vitiligo patients and the normal control group. The ANA positive rate in vitiligo patients and the normal control group were 8. 1% and 5. 7%respectively,and no statistical difference by comparison( P 0. 05). The A-TPO positive rate in patients with vitiligo were higher than that of normal controls( P 0. 05),they were 18. 8% and 10. 2% respectively. The A-TG positive rate in two groups are 25. 8% and 4. 5% respectively,the difference was strongly different by comparison( P 0. 001). Conclusion Part of the vitiligo patients may be suffering from the humoral immune disorder,and their pathogenesis may be related to autoimmune thyroid diseases; The values of immunoglobulin、Complements and ANA have no apparent application values in the treatment and evaluation of vitiligo patients.
【Fund】: 基金项目:首都临床特色应用研究(编号:Z11117058811086)
【CateGory Index】: R446.6;R758.41
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