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《Labeled Immunoassays and Clinical Medicine》 2017-11
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The Clinical Application of CKD-EPI Collaboration and Gate's Equation on the Evaluation of GFR of Elderly Patient with CKD by Taking Double-plasma-sample Method for Reference

YUAN Lei-lei;KAN Ying;WANG Yao;LIU Yue-long;WANG Na;YANG Ji-gang;Department of Nuclear Medicine,Beijing Friendship Hospital of Capital Medical University;  
Objective To compare the accuracy of CKD-EPI collaboration and Gate's equation on the evaluation of GFR of elderly patient with CKD by taking double-plasma-sample method for reference,and to explore the establishment of regression models. Methods 72 cases of elderly patients with CKD from April 2011 to January 2013 who were performed with both 99 mTc-DTPA renal dynamic imaging and doubleplasma-sample method were selected in our study. The accuracy of CKD-EPI collaboration and Gate' s equation on the evaluation of GFR of elderly patient with CKD were compared by taking double-plasmasample method for reference. Results The correlation between tGFR and g GFR was relatively high( r =0. 724),the correlation between tGFR and eGFR was low( r = 0. 632),and the difference was statistically significant( P 0. 05). The correlation between tGFR and eGFR or g GFR in stage 3 ~ 5 CKD elderly patients were both bigh,and the correlation coefficients were 0. 736 和 0. 749,respectively( P 0. 05). Conclusion Gate's equation can evaluate theGFR of elderly patients more accurately,but it is not recommended to be used as a method for reference of other formula' comparison. Both CKD-EPI collaboration and Gate' s equation can accurately be used in stage 3 ~ 5 CKD elderly patients,meanwhile when evaluating theGFR of elderly patients,comprehensive judgment is needed.
【Fund】: 北京市属医院科研培育计划(PX2017035);; 北京市医管局“使命”人才计划(SML20150101)
【CateGory Index】: R692;R817.4
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