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《Labeled Immunoassays and Clinical Medicine》 2017-11
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Clinical Value of Serum Procalcitonin in Estimation of Severity and Prognosis of Elderly Patients with Pneumonia

ZHAO Song-lin;NIE Xiu-hong;Xuanwu Hospital Capital Medical University;  
Objective To study the clinical value of serum procalcitonin on estimation of severityand prognosis of elderly patients with community-acquired pneumonia( CAP). Methods 120 cases of patients with elderly pneumonia treated in our hospital from June 2015 to April 2017 were selected asthe observation group,and divided into the low-risk group( 0-1 score),moderate-risk group( 2 scores) and high-risk group( 3-5 scores)according to the severity( CURB-65). At thesame time,72 cases of patients with non-infectious disease were selected as the control group,and the serum PCT and C-reactive protein( CRP) levels before and after treatment were compared and analyzed. The observation patients were separated into two groups according to their PCT level before treatment: the PCT ≤ 10 ng/m L group and PCT 10 ng/m L group. Then the difference of the prognosis was analyzed. Results The PCT and CRP levels in the observation group before treatment were higher than those in the control group with statistical significance [( 9. 24 ± 2. 05 ng/m L),( 48. 14 ± 5. 38 mg/L) vs( 0. 95 ± 0. 52 ng/m L),( 4. 46 ± 0. 68 mg/L) ],P 0. 05. In the observation patients,the level of PCT in low-risk group( 4. 33 ± 1. 48 ng/m L) was lower than that of the moderate-risk group( 8. 72 ± 2. 58 ng/m L) and the high-risk group( 19. 42 ± 3. 88 ng/m L),the difference was statistically significant( P 0. 05). The level of PCT in moderate-risk group was lower than that in high-risk group,the difference was statistically significant( P 0. 05). The PCT levels in the low-risk group and moderate-risk group significantlydecreased after treatment( P 0. 05). There was no significant difference in CRP level among low-risk group,moderate-risk group and high-risk group before treatment( P 0. 05),and there was no significantdifference compared with that before treatment( P 0. 05). The curative ratio in PCT ≤10 ng/m L group before treatment is higher thanthat in PCT 10 ng/m L group with statistical significance( P 0. 01). Conclusion There is a diagnosis valueof serumprocalcitoninfor elderly patients with pneumonia. It has positive correlation with the disease severity. And it has great value intherapeutic evaluation and prognosis estimation.
【CateGory Index】: R563.1
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