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《Labeled Immunoassays and Clinical Medicine》 2017-11
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Clinical Value of HE4,CA125 and ROMA in Differentiating Benign and Malignant Ovarian Masses

WANG Ya-fei;GUO Yu;WANG Hui-li;TUO Ya;WANG Li-juan;Department of Clinical Laboratory,the Affiliated Hospital of Inner Mongolia Medical University;  
Objective To evaluate the HE4,CA125 and ROMA in the differential diagnosis of ovarian carcinoma before operation. Methods Electrochemiluminescence was applied to detect serum HE4 and CA125 concentration in ovarian cancer group( n = 54) and benign ovarian mass group( n = 103),according to the menopause status to calculate the value of ROMA,and compare the diagnostic performance of HE4,CA125 and ROMA in both pre-and post menopause patients. Results Serum levels of HE4,CA125 and values of ROMA were higher in patients with ovarian cancer than those with benign ovarian l mass,and the difference was statistically significant( P 0. 001). The AUC for HE4,CA125 and ROMA in all patients were 0. 962,0. 899 and 0. 963,respectively. Serum markers in postmenopausal women had higher sensitivity than those in premenopausal patient( HE4: 91. 4 vs 84. 2%,CA125: 97. 1 vs 84. 0% and ROMA : 91. 4 vs 84. 6%,respectively). Serum levels of HE4,CA125 and ROMA in pre-and postmenopause patients were 92. 9 vs93. 6%,87. 5 vs 83. 0%,94. 6 vs 95. 7%,respectively. Conclusion HE4 and ROMA shows the better diagnostic performance to distinguish epithelial ovarian cancer from benign ovarian mass. High specificity of HE4 and ROMA is in differentiating benign ovarian mass from ovarian cancer,and CA125 has high sensitivity in postmenopausal women with ovarian cancer.
【Fund】: 2017年度内蒙古自治区科技计划项目
【CateGory Index】: R730.43;R737.31
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