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《Labeled Immunoassays and Clinical Medicine》 2017-11
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Diagnostic Value of Combined Detection of Blood Cell Parameters for Macrocytic Anemia

SHI Lei;LUO Zhi-cheng;WANG Hui;ZHANG Ming-Xin;Department of Laboratory,the Second Hospital,Lanzhou University;Department of Dermatology,the Second Hospital,Lanzhou University;  
Objective To investigate the diagnostic value of combined detection of blood cell parameters for macrocytic anemia. Methods We conducted the tests of the hematological index of erythrocyte parameters( HGB、MCV、MCH、MCHC、RDW-CV),reticulocyte parameters( Het% 、LFR、MFR、HFR、Ret-He、IRF)and platelet parameters( PLT 、MPV 、PDW 、IPF) by Sysmex XE-5000 automatic blood cell analyzer in 42 acute leukemia patients,30 hemolytic anemia( HA) patients,27 myelodysplastic syndrome( MDS) patients,24 megaloblastic anemia( MA) patients,15 multiple myeloma( MM) patients,and 50 normal controls. Results(1) The RDW-CV values of all disease groups were higher than that of the normal control group.Thedifferences ofRDW-CV value between HA group and other disease groups were statistically significant( P 0. 05).(2) The MFR、HFR、IRFvalues of all diseaase groups were higher than that of normal controlgroup,and the LFR value was lower than that of normal control group,the differences of MFR、HFR、IRF values of HA groups were statistically significant( P 0. 05). The Ret-He values of AL group,HA group,MA group,MMgroup were all higherthan those of normal control group. Thedifferences ofRet-He value between MDS group and other disease groups werestatistically significant( P 0. 05); the differences between MDS groups and normalcontrol group were not statistically significant( P 0. 05). 3 The PDW value of MDS group was higher than other disease groups,also the difference was statisticallysignificant( P 0. 05); the differences of MDS groups and normalcontrol group were not statistically significant( P 0. 05).Conclusion The alteration of blood parameters provides an important basis for the diagnosis of macrocytic anemia. They contributeto diagnosis and differential diagnosis of macrocytic anemia. They also provide directions for the selection of specific diagnostic tests forclinician.
【Fund】: 甘肃省自然科学基金(编号:145RJZA070)
【CateGory Index】: R446.11;R556
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