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《Labeled Immunoassays and Clinical Medicine》 2017-11
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Clinical Study of CD4/CD8 Cells and Coagulation Factor in Recurrent Spontaneous Abortion

HAN Li-rong;SONG Jiang-qin;GUO Fei-bo;LI Guang-mei;ZHANG Dong-wu;The First People's Hospital of Tianmen City;  
Objective To study the local expression of membrane tissue CD4,CD8 immune cells and TM,PAI-1,F_(1+ 2),D-dimers coagulation related factors in unexplained recurrent spontaneous abortion patients and their relevance,so to provide help for the treatment of patients with unexplained abortion. Methods The CD4/CD8 cells were counted and the CD4/CD8 ratio was calculated by immunocytochemistry. Using enzymelinked immunosorbent assay and adsorption test method in 50 patients with unexplained abortion( experimental group,non-pregnant) for plasma thrombomodulin( TM),plasminogen activator inhibitor-1( PAI-1),prothrombin fragment F_(1+ 2),D dimer( D-dimer,D-D) and the normal pregnancy factor concentration,and 50 women( control group) as control,the expression of the above two groups factors in two groups were measured,and then compared the results. Results Compared with the control group,TM,PAI-1 and F_(1+ 2) were highly expressed,and the expression of D-D was low. The difference between the two groups was statistically significant( P 0. 05). Conclusion The blood of patients with recurrent abortion was in a state of high coagulation and the fibrinolytic system was damaged. Restoration of the above status provides newideas for the treatment of unknown causes.
【Fund】: 湛江市医学类非资助科技攻关项目(编号:2016B101)
【CateGory Index】: R446.6;R714.21
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