Serum Level of Interleukin-6 in Colorectal Cancer and the Correlation Between the Kinetics of Interleukin-6 Levels and the Tumor Curative Effect
CHEN Yan-song;CHEN Na-juan;CHEN Yan;Department of Clinical Laboratory,Laboratory of Biochemistry and Molecular Biology Research,Fujian Provincial Key Laboratory of Tumor Biotherapy ,Fujian Cancer Hospital,Fujian Medical University Cancer Hospital;
Objective To investigate the expression of serum interleukin-6( IL-6) in colorectal cancer patients and the relationship between the IL-6 level and the tumor curative effect. Methods The electrochemiluminescence immunoassay was used to examine the serum level of IL-6 and carcino-embryonic antigen( CEA) in 132 colorectal cancer patients( CRC),35 inflammatory bowel disease( IBD),31 colorectal benign disease( CBD) and 84 healthy donors as healthy control group( HC). The relationship between IL-6 and clinicopathological features of colorectal cancer was analyzed,and ROC curve and binary losistic regression were applied to compare the diagnostic value of the IL-6 and CEA. The dynamic levels of serum IL-6 and CEA before and after treatment in 120 advanced CRC patients with complete case data was observed,and the relationship between IL-6 and CEA and the cruative effect of the tumor was analyzed.Results Both the serum IL-6 and CEA levels of the CRC were higher than IBD( P 0. 05,P 0. 05,respectively),CBD( P 0. 01,P 0. 05,respectively),and HC groups( P 0. 01,P 0. 01,respectively).Serum levels of the IL-6 was significantly correlated with tumor size,degree of tumor differentiation,pathological type,lymph node metastasis,distant metastasis and TNMstage( all the above,P 0. 05). The sensitivity and accuracy of IL-6 for CRC diagnosis were higher than CEA( 72. 7% vs 68. 2%,78. 6% vs77. 9%,respectively),while specifity was lower than CEA( 85. 2% vs 88. 9%). The combined detection of IL-6 and CEA were highest in sensitivity( 97. 2%) and accuracy( 85. 6%). After treatment,both the serum IL-6 and CEA levels significantly decreased in CR + PR + SD group( both P 0. 05),but not in the PD group( both P 0. 05). Conclusion The combined detection of serum IL-6 and CEA could be a useful potential diagnostic and therapeutic evaluation method for colorectal cancer.
【CateGory Index】： R735.34