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《Beijing Medical Journal》 2007-03
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The clinical significance of plasma NT-proBNPchanges in patients with coronary heart disease

ZHANG Jing-mei, LI Zhi-zhong, GAO Yu-long, et al(Emergency Center of Heart,Lung and Blood Vessel Disease,Beijing Anzhen Hospital,Beijing 100029)  
Objectives To evaluate plasma NT-proBNP levels in patients with stable angina,unstable angina and non-ST elevation myocardial infarction, and to study the relationshiop between the NT-proBNP levels and the severity and extent of coronary vessels involvement. Methods Nonextractable, enzyme-linked, sandwich immunoassay was used to measure the plasma NT-proBNP concentration in patients with acute coronary syndrome induding acute myocardial infarction (n=29), unstable angina pectoris(n=151), stable angina pectoris (SAP)group(n=165), and health controls (n=140). The parameters of heart function were measured by echocardiography. These paremeters were also measured in 180 ACS patients who underwent PCI. Results Plasma NT-proBNP levels in patients with ACS were significantly highter than those in the controls(P0.001), but the level in SAP group and the controls was not significantly different statistically(P0.05). But NT-ProBNP levels in the group increased significantly. Conclusions The plasma NT-ProBNP level in coronary artery diseases is increased and it can predict the severity of coronary heart diseases. The plasma NT-ProBNP level decreases markedly in patients who undergo PCI. Therefore it can be used as a a biochemical marker to evaluate the efficacy of PCI.
【Fund】: 国家973计划基金资助项目(2003CB517103)
【CateGory Index】: R541.4
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