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《Beijing Medical Journal》 2007-03
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The clinic and pathology of meningeal carcinomatosis complicating with cerebral venous sinus thrombosis (report of 4 cases)

DING Yan, DONG Hui-qing, PIAO Yue-shan, et al(Department of Neurology, Beijing Xuanwu Hospital, Beijing 100053)  
Objective To analyze the clinical characteristics of meningeal carcinomatosis (MC) complicating with cerebral venous sinus thrombosis(CVST). Methods The clinical features, image and pathological manifestations of 4 patients admitted to our hospital during 1990~2005 were retrospectively analyzed. Results One was male and 3 were female and their age ranged from 48 to 64 years old. The main complaint was headache and the symptoms of high intracranial pressure. 2 of them had the history of digestive tract tumor operation, 1 had hepatic cirrhosis, and 1 was failed to find any tumor. The intracranial pressures were significantly increased in all cases, and the ratios of sugar in cerebrospinal fluid (CSF) and that in blood were decreased. 2 MC cases were diagnosed by pathology in CSF, 1 was by autopsy and the last one had marked abnormality in image examination including PET and tumor marker, thought it was not supported by pathology in CSF. In the MRI examination, 3 of them had enlargement of lateral ventricle, and 1 was complicated with cerebral venous infarction. The diagnosis of CVST was performed by DSA examination in 3 cases, and MRV was used in the other one. Conclusions The symptom of high intracranial pressure is mild in old patient but develops quickly in the late stage. It maybe indicate MC complicating with CVST if the patient has CVST with enlargement of lateral ventricle but without cerebral changes in image examination, or the clinical manifestation is not consistent with the severity of CVST.
【CateGory Index】: R739.45
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