Clinical significance of serum levels of soluble Fas、soluble Fas ligand and soluble Ⅱ-2 receptor in patients with dilated cardiomyopathy
GE Chang-jiang, LU Shu-zheng, Chen Yun-dai(Department of Cardiology, Beijing Anzhen Hospital, Beijing 100029)
Objective To evaluate the relationship between serum levels of soluble Fas、soluble Fas ligand and solub IL-2 receptor, and dilated cardiomyopathy(DCM). Methods By specific enzyme-linked immunosorbent assay(ELISA)tests, soluble Fas、soluble Fas ligand and soluble IL-2 receptor were measured in the sera of 30 patients with DCM(DCM group),and 22 controls(Control group). Results Mean levels of soluble Fas and soluble IL-2 receptor were significantly higher in patients with DCM than those in controls(P0.01). Compared with Control group, the mean level of soluble FasL was lower in DCM group, but the difference was not significant. Mean levels of soluble Fas and soluble IL-2 receptor were elevated parallel with the grades of heart function(NYHA Grade Ⅰ-Ⅳ). Moreover, soluble Fas and soluble IL-2 receptor were positively correlated in patients with DCM(r=0.441, P0.05). Conclusions Our study demonstrates that levels of soluble Fas and soluble IL-2 receptor in patients with DCM are elevated, which suggests that they may relate to DCM. Serum soluble Fas may facilitate pathogenesis of DCM by perpetuating autoimmune-inflammatory reactions and cardiomyocyte apoptosis.
【CateGory Index】： R542.21