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《Beijing Medical Journal》 2007-03
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Effects of atorvastatin and captopril on the extracellular matrix of rat mesangial cells cultured under high hydrostaticpressure

SHEN Yun-feng,CHENG Xiao-shu,XU Jin-song,et al(Department of Cardiology,The Second Affiliated Hospital of Nanchang University,Nanchang 330006)  
Objective To investigate the effects of atorvastatin and captopril on the extracelluar matrix(ECM) of rat mesangial cells (RMC) under continual high hydrostatic pressure. Methods RMCs were exposed to physiological pressure (40 mm Hg,PP),moderate pressure (60 mm Hg,MP),high pressure (80 mm Hg,HP ) 1 3 5 7 days respectively. Each pressure condition was satisfied in five groups: control captopril (10 μmol/L) atorvastatin (10 μmol/L) captopril+atorvastatin(10μmol/L+10μmol/L) and dimethylsulfoxide. The treatment group contentration of FN,collagenⅠ Ⅳ were tested with western blotting in the supernatant of lysate. Results Compared with the 1st day of PP,the level of collagenⅠ was elevated significantly from 1st day on MP and HP,dchieved the highest level at 7th day. The change of FN,collagen Ⅳ were similar to collagenⅠ. Both atorvastatin and captopril could partly inhibit the elevation of extracellular matrix(collagen Ⅰ:1 d,atorvastatin:1.06±0.12,1.16±0.14 vs 0.78±0.05;captopril:0.96±0.09,1.02±0.13 vs 0.71±0.06; P0.05). Atorvastatin combined with captopril can decrease collagenⅠ collagen Ⅳ and FN better. Conclusions The recurrent fluctuant static pressure above physiological pressure can induce the accumulation of ECM. Both atorvastatin and captopril can inhibit the deleterious effects of high hydrostatic pressure. Captopril and atorvastatin are synergistic.
【Fund】: 国家自然科学基金资助项目(30260037)
【CateGory Index】: R544.1
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【Citations】
Chinese Journal Full-text Database 6 Hits
1 WANG Xin, LIU Chao, LIU Cui-ping, YANG Tao, WU Xiao-hong, WEI Qun-li,(Department of Endocrinology, the First Affiliated Hospital of NJMU, Nanjing 210029, China);Effect of Atorvastatin on Proliferation and Cell Cycle of Rat Mesangial Cells under High Concentration of Glucose[J];Acta Academiae Medicinae Nanjing;2004-06
2 LIU Chao, YANG Tao, CHEN Jia、wei, LIU Cui、ping(The First Affiliated Hospital of Nanjing Medical University, Nangjing, Jiangsu, 210029);THE EFFECT OF LOVASTATIN ON THE EXPRESSION OF TRANSFORMING GROWTH FACTOR、β_1 AND EXTRACELLULAR MATRIX IN THE HUMAN MESANGIAL CELLS[J];Journal of Jiangsu Clinical Medicine;2004-04
3 SHEN Yun-feng, CHENG Xiao-shu, XU Jing-song, YANG Ren-qiang, DONG Yi-fei, SU Hai, WU Qing-hua, WU Yan-qin. Department of Cardiology, the second affiliated hospital of Nanchang University, Nanchang, JiangXi 330006, China;Effects of Atorvastatin and Captopril on the Proliferation of Rat Mesangial Cells Cultured under High Hydrostatic Pressure[J];;2006-01
4 Wang Li; Pan Changyu(Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853);Effect of captopril on Ca~(2+)of rat glomerular mesangial cells[J];CHINESE JOURNAL OF DIABETES;1998-04
5 SHI Wei, LIANG Xingllng, LIUShuangxin, et al. Department of Nephrology, Guangdong Provincial People's Hospital, Guangzhou 510080, China;Effect of transforming growth factor beta 1 antisense RNA by adenovirus mediation on synthesis and secretion of extracellular matrix in cultured mesangial cells[J];Chinese Journal of Nephrology;2002-02
6 YE Wen-ling,LI Xue-wang,XU Cai-min,LI Hang,LI Yan,DUAN Lin,JIN Jing. Division of Nephrology, Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730, China;Effect of simvastatin on PMA-induced expression of type A scavenger receptor in human glomerular mesangial cells[J];Chinese Journal of Nephrology;2006-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Chen Ming et al (Beijing University of Chinese Medicine, Beijing);Effect of Modified Zhuling Tang on IL-6 in Mesangium Cell[J];China Journal of Traditional Chinese Medicine and Pharmacy;1999-04
2 Wang Haiyan;Zhao Zhihui Nephrology Centre,First Hospital;THE EFFECT OF IL-1 AND TGFβ IN PROGRESSIVE MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS[J];;1992-04
3 CHEN Jian-Liang; LI Xiao-Mei; WANG Hai-Yan (Division of Nephrology, the First Hospital, Beijing Medical University, Beijing 100034);Inhibition of interleukin-10 on intercellular adhesion molecule-1 expression in human mesangial cells mediated by a decreased activity of nuclear factor κB[J];Journal of Beijing Medical University;1999-02
4 LI Mei Hua 1, CHEN Yi Pu 1, ZHANG Zhi Wen 2 (1 Division of Nephrology, Peking University First Hospital, Beijing 100034, China; 2 Department of Physiology, Peking University School of Basic Medical Sciences);Inhibition of human glomerular mesangial cell proliferation with antisense oligodeoxynucleotide targeting preproendothelin1 mRNA[J];Journal of Beijing Medical University;2001-06
5 Qiu Hongyu;Qu Suiliin;Liu Xiaohui;Yang Lichuan (Nephrology Division,Department of Internal Medicine, the First Affiliated Hospital, WCUMS, Chengdu, Sichuan 610041);The Effects of Fluctuating Extracellular High Glucose Concentration on Glomerular Mesangial Cells[J];CHONGQING MEDICAL JOURNAL;1999-06
6 GUO Zhi Yong, CUI Ruo Lan (Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai 200433,China);Role of intercellular adhesion molecule 1 in glomerular inflammation and effects of losartan on it[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;2000-01
7 MEI Xiao- Bin1 ,GAO Cong- Rong2 ,CU I Ruo- L an1 ,YUAN Wei- Jie1 ,YE Zhi- Bin1 (1.Department of Nephrology,Changhai Hospital,Second Military Medical University,Shanghai 2 0 0 4 33,China;2 .Department of Endocrinology,Changhai Hospital);Aminoguanidine attenuating high-glucose-induced hypertrophy of mesangial cell through decreasing cyclin kinase inhibitor P27[J];Academic Journal of Second Military Medical University;2002-02
8 YIN Yong-hong~1,Lu Shen~2(1.Department of Nephrology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China;2.Laboratory Center,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China);Effect of fluvastatin on production of extracellular matrix in glomerular mesangial cell[J];Journal of Dalian Medical University;2006-04
9 $$$$;Improvement of glomerular mesangial cell culture 10 vitro[J];ACTA ACADEMIAE MEDICINAE MILITARIS TERTIAE;1994-05
10 Sun Min, Fan Hongwei, Han Bing, et al. 2001 Grade doctorate, Nanjing University of Traditional Chinese Medicine, Nanjing 210019, China. National Standard Laboratory of Pharmacology for Chinese Meteria Medica, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China;The effect of high glucose and advanced glycation end products on the proliferation of bovine glomeruli mesangial cell[J];Fujian Medical Journal;2004-02
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Li 2, MEI Chang Lin 1, TIAN Yi Hua 3, WANG Yong Wu 4 (1. Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; 2. Department of Nephrology, General Hospital of People′s Police Force, Shangh;Effects of low density lipoprotein on the growth of mesangial cells, the expression of transforming growth factor-β and fibronectin mRNA[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;2000-03
2 CAO Hong, YANG Tao, LIU Chao, LIU Cui-ping, CHEN Jia-wei (Department of Endocrinology, the First Affiliated Hospital of NJMU, Nanjing 210029, China);The Effect of Simvastatin on the Proliferation of Glomeruli Mesangial Cells and the Secretion of Extracellular Matrix Proteins under High Concentration of Glucose[J];Acta Academiae Medicinae Nanjing;2003-01
3 WANG Xin, LIU Chao, LIU Cui-ping, YANG Tao, WU Xiao-hong, WEI Qun-li,(Department of Endocrinology, the First Affiliated Hospital of NJMU, Nanjing 210029, China);Effect of Atorvastatin on Proliferation and Cell Cycle of Rat Mesangial Cells under High Concentration of Glucose[J];Acta Academiae Medicinae Nanjing;2004-06
4 Chen Shaoxing; Guo Jizhen; Qiang Weiguo;, et al (Do partment of Hypertension, Shanghai Institute of Hypertension, Ruijim Hospital, Shanghai Second Medical University, Shanghai 200025);Effect of An Angiotensin Ⅱ Receptor Antagonist on the Proliferation of Glomerular Mesangial Cells from Spontaneously Hypertensive Rats[J];ACTA UNIVERSITATIS MEDICINALIS SECONDAE SHANGHAI;1999-04
5 SUN Tianmei,MEI Changlin,GE Shouyi,XU Chenggang Depatment of nephrology,Changzheng Hospital,Second Military Medical University. Shanghai,200003;Effect of lovastatin on proliferation and extracellular matrix secretion of rat mesangial cells in culture[J];Chinese Journal of Nephrology, Dialysis & Transplantation;2001-05
6 WANG Yunkai,SU Hai,CHENG Xiaoshu (Department of Cardiology, The first Affiliated Hospital, Jan Xi Medical College, Nanchan 330006);The Effects of High Pressure Culture and Drug Intervention on Functions of Porcine Aorta Endothelial Cells in vitro[J];CHINESE JOURNAL OF HYPERTENSION;2000-01
7 Wang Li; Pan Changyu(Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853);Effect of captopril on Ca~(2+)of rat glomerular mesangial cells[J];CHINESE JOURNAL OF DIABETES;1998-04
8 SHI Wei, LIU Shuangxin, LIANG Xingling, et al. (Department of Nephrology, Guangdong Provincial People's Hospital, Guangzhou 510080, China);Construction of transforming growth factor beta 1 antisense RNA recombinant adenovirus[J];Chinese Journal of Nephrology;2001-02
9 LI Hang, LI Xuewang, DUAN Lin, et al. (Department of Nephrology, Peking Union Medical College Hospital. Beijing 100730, China);Inhibitory effects of Iovastatin on activation of NF-κB and expression of cytokines in glomerular mesangial cells[J];Chinese Journal of Nephrology;2001-04
10 HE Jingsong, HANDexuan. Department of Nephrology, Nanjing Gulou Hospital, Nanjing University School of Medicine, Nanjing 210008, China;Effect of lovastatin on proliferation of cultured rat mesangial cells[J];Chinese Journal of Nephrology;2002-02
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