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《Chinese Journal of Blood Transfusion》 2007-01
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A study of HLA-B~*27 subtypes and their association with ankylosing spondylitis

CHEN Changrong, ZHANG Zhongying, NI Hongying, et al. Xiamen Blood Center, Xiamen 361004 China  
Objective To compare the frequencies of HLA-B*27 genetic subtypes in AS patients with those of unrelated Fujian donors from Chinese Marrow Donor Program. The association of AS with HLA-B*27 genetic subtypes was also investigated. Methods HLA-B*27 gene and genetic subtypes were determined by PCR-SSO and PCR-SSP methods. Results In unrelated donors group we found 7 subtypes of HLA-B*27 gene, that were B*2703、B*2704、B*2705、B*2706、B*2707、B*2711、B*2720. And alleles of B*2704、B*2705、B*2707、B*2711、B*2715 were found in AS patients. The HLA-B*27 genetic subtype frequencies of the two groups were not found statistical difference(P0.05). Conclusion The polymorphism distribution of HLA-B*27 genetic subtypes between unrelated donors and AS patients might have no significant difference.
【Fund】: 福建省卫生厅青年科研课题(编号:2004-1-29)
【CateGory Index】: R593.23
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Chinese Journal Full-text Database 2 Hits
1 Pan Ke-nv1,Yang Wen-bo2,Tan Deng-ling2 (1.The Frist People′s Hospital of Hangzhou,Hangzhou 310006,China;2.Hangzhou D.A.Medical Laboratory,Hangzhou 310000,China);Establishment of HLA-B27 polymerase chain reaction system and its initial clinical application[J];Chinese Journal of Health Laboratory Technology;2008-06
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1 LI Wei1 HUANG Xia2(1Chongqing Blood Center,Chongqing,400015,China;2Department of Epidemiology,the Third Military University,Chongqing);Study on association between HLA-B27 allele subtypes and ankylosing spondylitis[J];Journal of Clinical Hematology (Blood Transfusion & Laboratory Medicine Edition);2007-05
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