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《Chinese Journal of Blood Transfusion》 2007-01
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The relationship between the IgG anti-body titers, the concentration of IgG subclasses of group O pregnant women and ABO hemolytic disease of newborn

ZHANG Chenguang, WU Zizhao, WANG Yarong, et al. Department of Laboratory Medicine of Xinxiang Medical College, Xinxiang 453003, China  
Objective To study the relationship between the IgG antibody titer, the concentration of IgG subclasses in group O maternal sera and hemolytic disease of newborn. Methods By means of blood group serology assay, IgG antibody titers in 317 pregnant women who had incompatible blood group with their husbands was measured. The concentration of IgG subclasses were measured in HDN infants and their mothers, healthy pregnant women and healthy infants by ELISA. Results 1) Among 317 maternal sera, 153 cases (48.3%) were found to have IgG antibody titers higher than 1∶64, with anti-A and anti-B in 89 and 64 cases, respectively. Seventy-one (22.4%) newborns suffered from ABO-HDN, with 46 anti-A and 25 anti-B; 2) With increased numbers of pregnancy, the proportions women with greater than 1∶64 IgG antibody increased, and there was significant difference between those with one pregnancy and those with more than one pregnancies; 3) The levels of IgG antibody in HDN infants and their mothers were higher than those in control group, and IgG1 was the predominant subclass. Meanwhile, the proportion of IgG1 in infants was higher than in pregnant women. Conclusion To some couples of ABO incompatibility, IgG antibody titer and IgG subclasses should be tested in pregnant women. The incidence of HDN increases with increased antibody titers. The severity of HDN correlates positively with the concentration of IgG1 in maternal sera.
【Fund】: 新乡市科技项目(编号:05S003)
【CateGory Index】: R722.1
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【References】
Chinese Journal Full-text Database 10 Hits
1 DENG Li ping LI Zhong-jun (Department of Blood Transfusion,Xinqiao Hospital.Third Military Medical University,Chongqing 400037,China);Prediction of ABO hemolytic disease of newborn using ABO blood group anti-A(B)antibody in pregnant women[J];Chongqing Medicine;2007-24
2 ZHOU Yi-qiang,XIAO Qian,FENG Shang-ke,TANG Ren-guang.Department of Transfusion,Baise City People's Hospital,Baise 533000,China;Correlation study between IgG subclasses and neonatal ABO hemolytic disease[J];Guangdong Medical Journal;2011-02
3 WANG Ji-dong1,ZHANG Chen-li1,PANG Gui-zhi1,KE Qiu-ping2,LOU Bai-min1;Relationship between Titer of Blood Group Antibodies of Pregnant Women with ABO or Rh Blood Type Incompatibility and Exchange Transfusion in Hemolytic Disease of Newborn Infants[J];Journal of Applied Clinical Pediatrics;2009-18
4 LI Xue-ying1,LI Zhi-ping1,WANG Min1,SHI Wen-jie2;Relationship of Immunoglobulin G Blood Antibodies in Pregnant Women and Hemorrhagic Disease in Newborns[J];Journal of Applied Clinical Pediatrics;2011-17
5 YUAN Zhi-jun1,ZHANG Jing-jing2,ZHU Lin-lin2,ZHANG de-yan1 (1.General Hospital of Puyang Oil field,Puyang,He’nan 457001,China;2.Xinxiang Medical College,Xingxiang,He’nan 453003,China);Analysis of the Relationship between the Valence of IgG Antibody A(B) on Pregnant Women with Blood Type O and Hemolytic Disease of Newborn[J];Journal of Practical Medical Techniques;2008-11
6 PANG Hai-yun,FU Sheng-miao,FU Jiao,et al.(Central Laboratory,Hainan Provincial People's Hospital,Haikou 570311,Hainan,P. R. China);Detection of TORCH-IgM in 2617 pregnant women of childbearing age in Haikou City[J];China Tropical Medicine;2012-08
7 RU Keya·abulai,MAI Diniyati·Maimaiti,RE biya·Maimaiti,GULaibaier,GULipiya·Aihait(Xinjiang Uygur Autonomous Region People's Hospital,Department of Neonatology,830001,Uruumqi,China);The Clinical Analysis of Risk Factors About ABO Type Hemolytic Disease of the New-born[J];Progress in Modern Biomedicine;2012-26
8 LI Xiaozhou1 LI Bo2 DAI Hongwei1 ZHOU Jiao1 YANG Xuemin1 ZHOU Jie1(1Department of Blood Transfusion,Suizhou City Central Hospital,Suizhou,441300,China;2Department of Obstetrics and Gynecology);Pregnant women plasmapheresis treatment serum IgG and blood changes in the environment[J];Journal of Clinical Hematology;2013-04
9 ZHANG Chen-Guang,WANG HuiDepartment of Medical Laboratorial Examination, Henan Xinxiang Medical College, Xinxiang 453003, Henan Province, China;Immune Hemolytic Diseases Caused by Irregular Antibodies and Its Research Advance in Clinic——Review[J];Journal of Experimental Hematology;2010-03
10 REN Xiao-kun,et al.(Third People′s Hospital of Zhengzhou City Laboratory,450000);Correlation factor analysis on haemolytic disease of the newborn[J];Chinese Journal of Birth Health & Heredity;2011-11
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Li Da peng,Xu Xue fang,Ren Hong, Wang Ya juan (Department of Blood Transfusion,the 88th Hospital of PLA,Tai an 271000,China);Determination of Level of Biood Type Antibody and its Clinical Significance Before Delivery[J];Journal of Clinical Medical Officer;2003-02
2 CHEN Yue-xiang, CHU Kai-qiu.Department of Blood Transfusion, Department of Laboratory, the Affiliated Hospital of Medical College,Qingdao University,Qingdao,266003.;RELATIONSHIP BETWEEN THE VALENCE OF ANTIBODY OF PREGNANT WOMAN WITH BLOOD TYPE O IN SERUM AND HEMOLYTIC DISEASE OF NEWBORN.[J];Modern Preventive Medicine;2005-09
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Yong-ding1,CHEN Li1,LI Jin-song1,DING Zhou-zhi2(1.Department of Laboratory Medicine,Shenzhen Xili People's Hospital,Shenzhen 518055;2.Department of Pediatrics,Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China);Relationship between anti-A(B)IgG titers of pregnant women and neonatal jaundice[J];Journal of Bengbu Medical College;2007-02
2 ZHU Ying1,2,MAO Hui-ling1,QIU Fang2(1.School Of Life Sciences And Food Engineering,Nanchang University,Nanchang,Jiangxi 330031;2.The First Affiliated Hospital Of Gannan Medical University,Ganzhou,Jiangxi 341000);The Application of Prevent HDN With The Determination of Anti-A(B)IgG Titers of Pregnant Women by Improved Coombs' Test[J];Journal of Gannan Medical University;2011-01
3 YAN Da-gang1,CAO-Yan1,YANG Bao-guo1,WANG Yi-feng2(1.Department of Blood transfusion;2.Obstetrics Gynecology Department,Medical treatment battalion,Central Hospital of PanZhiHua,SiChuan Province,617067);The PCR Technology in the Early Diagnosis of Feto-Maternal ABO Blood Incompatibility[J];Journal of Chengdu Medical College;2012-04
4 Yu Xiao,Zhang Tao,Luo Wen-juan(Department of Blood Transfusion,the Yibin No.2 People's Hospital of Sichuan Province,Yibin 644000,China);The Relationships Between IgG Antibody Titer in Maternal Plasma of O Blood Types and Maternal Age,Gestational Weeks,Times of Pregnancy[J];Journal of Chengdu Medical College;2013-03
5 XIE Yiwei,People's Hospital of Zhejiang Province,Hangzhou 310014,China;Determining indoor reference value of titer of anti-A/B IgG antibody in the pregnant women's serum using microcolumn gel assay[J];Clinical Education of General Practice;2009-05
6 CHEN Yan-xia,CHEN Chuan-bi,LI Zhi-guang(Sanya Municipal Maternal Hospital,Sanya 572000,Hainan,P.R.China);Correlation of clinical features of neonatal ABO hemolytical disease with serum antibody titres in the mothers[J];China Tropical Medicine;2010-05
7 LI Shuang,LIU Chang,QIN Yan-ling(1.Nanxishan Hospital,Guilin 541002,Guangxi,P.R.China);Detection of antibody to ABO blood group of 215 pregnants with O blood group for predicting hemolysis in the newborns[J];China Tropical Medicine;2011-01
8 YU Li-ying~(1),CAO Ming~(2),LIU Shao-xian~(1)(1.The People's Hospital of Langfang,Hebei Langfang 065000,China; 2.Department of Pediatrics,The People's Hospital of Mian County,Shaanxi Mian County 724200,China);A clinical analysis of 56 cases of neonatal hemolytic disease due to ABO incompatibility[J];Chinese Journal of Maternal and Child Health Research;2006-03
9 XIE Jing-wen,WEI Yan-fen(Panyu Blood Centre of Guangzhou City,Guangzhou 511400,China);Relationship between Anti-A / Anti-B IgG Titer of Pregnant Women and Morbidity of Hemolytic Disease of Newborn[J];Chinese Journal of Biologicals;2011-12
10 XU Jinming ZHOU Xiaoyu HUA Lan SUN Yunyu YANG Jinzhu(Department of Blood Transfusion,the First Affiliated Hospital of Nanjing Medical University,Nanjing,210029,China);Significance of blood group antibody titer detection in prenatal diagnosis[J];Journal of Clinical Hematology;2009-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 TANG Ming-xia(Department of Pediatrics,Tongling People's Hospital,Tongling,Anhui 244000,China);Cause of neonatal hyperbilirubinemia:analysis of 236 cases[J];Anhui Medical and Pharmaceutical Journal;2010-05
2 Zhao Lei1,Yin Hang1,Lv Lin2,et al 1.ZheJiang Chinese Medical University,Hangzhou(310053);2.The Secound Affiliated Hospital of Zhejiang Chinese Medical University;Research the Clinical Prevention and Treatment of XiaoHuangyin for The ABO Maternal-Fetal Blood Group Incompatibility[J];Journal of Zhejiang Chinese Medical University;2012-06
3 XIAO RUI-qing,LIN WU-cun,ZENG Jie,et al.(Department of Blood Transfusion,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Comparative analysis of two methods for examination of newborn hemolysis[J];Chongqing Medicine;2006-11
4 LUO Mei,HE Jing,CHEN Fang-xiang,et al.(Department of Blood Transfusion,Daping Hospital and Research Institute of Field Surgery,Third Military Medical University,Chongqing 400042,China);Results of serological determination of blood samples from 199 patients with hemolytic disease of newborn[J];Chongqing Medicine;2006-11
5 LUO Mei CHEN Fang-xiang HE Jing (Department of Blood Transfusion,Daping Hospital,Research Institute of Surgery,Third Military Medical University,Chongqing 400042,China);Comparison of diagnostic effectiveness of papain Coombs test and microculumn gel Coombs test on hemolytic disease of newborn[J];Chongqing Medicine;2007-24
6 XIAO Rui qing, Zhao Shu ming, LIN Wu cun, LONG Xiao qiu, LIU Jing han (Department of Transfusion, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Investigation and analysis of anti-A/B complete and incomplete antibody titers in blood group O serum[J];Acta Academiae Medicinae Militaris Tertiae;2003-10
7 MA Shu-xuan, BAI Li-xia, LIU Jing-han, OUYANG Xi-lin, LI Xi-jin (Clinical Transfusion Center, General Hospital of PLA, Beijing 100853, China);Comparison of four methods for determination of IgG red blood cell antibodies[J];Acta Academiae Medicinae Militaris Tertiae;2005-07
8 GUI Qin, WANG Yu, CHEN Jing, WU Li-qiang (Department of Pediatrics, Southwest Hospital, Third Military Medical University, Chongqing 400038,China);Relationship between ABO hemolytic disease of newborn and maternal antibody[J];Acta Academiae Medicinae Militaris Tertiae;2007-07
9 HUANG Wei-min, CHEN Hong-wu, LI Ning, YANG Ming, JIAO Pei-yan Department of Neonatology, Nangfang Hospital, Southern Medical University, Guangzhou 510515, China;Clinical study of early interventions for ABO hemolytic disease of the newborn[J];Journal of Southern Medical University;2006-09
10 ZHOU Yi-qiang,XIAO Qian,FENG Shang-ke,TANG Ren-guang.Department of Transfusion,Baise City People's Hospital,Baise 533000,China;Correlation study between IgG subclasses and neonatal ABO hemolytic disease[J];Guangdong Medical Journal;2011-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Zhao Li(Department of Blood Transfusion,First people's hospital in Xuzhou,Jiangsu 221002,China);The role of irregular antibodies screening in preventing hemolytic transfusion reaction[J];International Journal of Laboratory Medicine;2011-20
2 Lu Huanxing,Huang Yuelan,Wen Junjie(Department of Blood Transfusion,the Center Hospital of Jiangmen,Jiangmen,Guangdong529000,China);Significance of serological testing in hemolytic disease of newborn[J];International Journal of Laboratory Medicine;2012-11
3 XIA Ai-jun;FAN Wenxi;ZHANG Xianqing;CHEN Chen;YU Rui;Department of Transfusion Medicine,Xijing Hospital,the Fourth Military Medical University;Xi'an Jiaotong University Health Science Center;;The clinical significance of the lgG subclasses on the pregnant women with the high titer IgG antibody[J];Chinese Journal of Blood Transfusion;2014-02
4 Wang Conggang;Chen Jing;Bao Jianguo;Zhu Shuqi;Rong Fazhi;Gui Xiufang;Mao Yusheng;Department of Blood Transfusion,Chizhou Municipal People′s Hospital;;Analysis of test results of ABO hemolytic disease of newborn in Chizhou area[J];International Journal of Laboratory Medicine;2015-05
5 Zou Jiaoli;Wang Qing;Zou Wentao;He Ziyi;Wang Ruoheng;Chen Qingkai;Cui Siping;Dongguan Blood Center;;The application of cassette automatic blood analyzer in irregular antibody screening for blood donors[J];International Journal of Laboratory Medicine;2015-12
6 Yang Guilin;Chu Lijuan;Li Chunli;Tan Shi;Song Tao;Li Qiuhong;Department of Clinical Laboratory,Chongqing Maternal and Child Health-Care Hospital;;The comparasion of effect between Thermal elution test in 56 ℃ and Freezing thawing test in-20 ℃for neonatal ABO haemolytic disease[J];International Journal of Laboratory Medicine;2015-16
7 CAI Yu-xu,ZHANG Ya-qing.Department of Clinical Transfusion Hainan Provincial Blood Center,Haikou 570311,Hainan,CHINA;Statistical analysis on the results of the serological testing for hemolytic disease in 290 newborns[J];Hainan Medical Journal;2013-02
8 MA Yin-tu;LI Li-hua;LI Yu-qiu;ZHANG Jing;SONG Jun-zhen;Department of Blood Bank,Bethune International Peace Hospital of PLA;Department of Blood Screening,Blood Center of Hebei Province;;Micro Column Gel Technique Assay in Detection of Blood-group Substances in Yinzhihuang Oral Liquid[J];Medical & Pharmaceutical Journal of Chinese People's Liberation Army;2014-02
9 LI Dong-hui;HUANG Jie-li;GAO Yu-jie;ZHANG De-jiu;Departemnt of Gyenology,Zhuhai Second People's Hospital in Guangdong;;Relationship between Maternal-fetal ABO-incompatible Maternaligg Antibody Titer and Hemolytic Disease of the Newborn[J];Military Medical Journal of South China;2014-06
10 ZHOU Pei-shan;HUANG Qun;XU Shao-yu;Department of Obstetrics and Gynecology, Jieyang People's Hospital;;Correlation between Ig G antibody tilter and hemolytic disease of the newborn in pregnant women with maternal-fetal ABO blood type incompatibility[J];Hainan Medical Journal;2015-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 NIE Chuan, LIU Guo-sheng, YANG Hui, ZHAO Xiao-peng (Dept. of Pediatrics, First Affiliated Hospital, Medical College, Jinan University, Guangzhou 510630, China);The relationship between the titer of serum IgG antibody of type O gravidas and HDN with jaundice[J];Journal of Jinan University(Natural Science & Medicine Edition);2002-06
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