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《Chinese Journal of Blood Transfusion》 2014-01
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Characteristic and structure analysis of CD36 deficiency in Han,Zhuang and Yao population from Guangxi region in China

in China;ZHONG Zhoulin;SHEN Weidong;ZHOU Yan;LIU Jinlian;LI Haiyan;LU Fang;WU Guoguang;Nanning Institute of Transfusion Medicine;  
Objective To investigate the incidence of CD36 deficiency and characteristics of Han,Zhuang and Yao nationality individuals from Guangxi region.Methods Platelet immunouorescence test-flow cytometry(PIFT-FC) assay was setup to screen CD36 deficiency from Han,Zhuang,and Yao nationality non-related donors,and the results were checked by monoclonal antibody-specific immobilization of platelet antigens(MAIPA) assay,then expression of CD36 on monocyte was analysed by Monocyte Immuno uorescence Test-Flow Cytometry(MIFT) to classify the types of CD36 deficiency.Results 4 621 samples were screened,of which 191 were CD36 deficiency by PIFT and MAIPA assays.The incidence of CD36 deficiency was 4.13%(191 /4 621),while the incidence of Han ethnic population was 3.59%(109 /3 036),Zhuang was5.76%(80 /1 389),Yao was 2.38%(2 /84).117 of 191 CD36 deficiency donors were classified the types of CD36 deficiency.It showed that the overall proportion of type Ⅰ was 41.03%(48 /117),and Han ethnic population was 39.19%(29/74),Zhuang was 43.90%(18/41),Yao was 50%(1/2).while type Ⅱ was 58.97%(69/117),Han was 60.81%(45/74),Zhuang was 56.10%(23/41),Yao was 50%(1/2),respectively.Conclusion The incidence of CD36 deficiency of Guangxi population is 4.13%,while the proportion of type Ⅰ deficiency is 41.03%.Different ethnic groups are statistically significant differences on the structure of CD36 deficiency.The incidence of CD36 deficiency of Zhuang population was much higher than other nationality,which exhibit unique characteristics of Zhuang nationality.
【Fund】: 广西科学研究与技术开发计划项目(主席基金)(081 60-06);; 南宁市科学研究与技术开发计划项目(科技惠民重大科技专项)(20133141)
【CateGory Index】: R446.11
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【References】
Chinese Journal Full-text Database 1 Hits
1 Zhou Yan;Zhong Zhoulin;Liu Jinlian;Li Lilan;Shen Weidong;Wu Guoguang;Nanning Blood Center/Nanning Institute of Transfusion Medicine;;Establishment of platelet antigen panel cells and application in platelet alloantibody detection[J];Chongqing Medicine;2014-25
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【Co-citations】
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1 ;Research progress on relationship between CD36gene deficiency and alloimmune thrombocytopenia[J];Journal of Jilin University(Medicine Edition);2012-06
2 SHEN Weidong;LI Lilan;LIAO Yan;ZHAO Tongmao;WU Guoguang;Nanning Institute of Transfusion Medicine;National Institutes of Health,NIH,USA;;Study on multi-PCR-SSP technique for HPA-1 ~ 17bw genotyping and the distribution of HPAs polymorphism in Chinese Zhuang population[J];Chinese Journal of Blood Transfusion;2014-01
3 WU Guoguang;ZHOU Yan;ZHONG Zhoulin;LI Lilan;LIU Jinlian;SHEN Weidong;Nanning Institute of Transfusion Medicine;;Experimental study on the platelet transfusion refractoriness mediated by the anti-CD36:four cases reports in China[J];Chinese Journal of Blood Transfusion;2014-01
4 ;The laboratory detection research progress of platelet transfusion refractory[J];Journal of Clinical Hematology;2013-05
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【Co-references】
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1 LIAO Yan,SHEN Weidong,LI Lilan,et al.Corresponding author:WU Guoguang. Nanning Institute of Transfusion Medicine,Nanning Blood Center,Nanning 530003,China;Genetic frequency distribution of human platelet antigens 1—16bw in Nanning population in China[J];Chinese Journal of Blood Transfusion;2010-06
2 WU Guoguang;ZHOU Yan;ZHONG Zhoulin;LI Lilan;LIU Jinlian;SHEN Weidong;Nanning Institute of Transfusion Medicine;;Experimental study on the platelet transfusion refractoriness mediated by the anti-CD36:four cases reports in China[J];Chinese Journal of Blood Transfusion;2014-01
3 ZHOU Yan;ZHONG Zhou-Lin;LI Li-Lan;SHEN Wei-Dong;WU Guo-Guang;Nanning Institute of Transfusion Medicine,Nanning Blood Center;;Detection,Diagnosis and Analysis of the First Case of Neonatal Alloimmune Thrombocytopenia Purpura Associated with AntiHPA-5b in China[J];Journal of Experimental Hematology;2014-02
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