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Characteristic and structure analysis of CD36 deficiency in Han,Zhuang and Yao population from Guangxi region in China

in China;ZHONG Zhoulin;SHEN Weidong;ZHOU Yan;LIU Jinlian;LI Haiyan;LU Fang;WU Guoguang;Nanning Institute of Transfusion Medicine;  
Objective To investigate the incidence of CD36 deficiency and characteristics of Han,Zhuang and Yao nationality individuals from Guangxi region.Methods Platelet immunouorescence test-flow cytometry(PIFT-FC) assay was setup to screen CD36 deficiency from Han,Zhuang,and Yao nationality non-related donors,and the results were checked by monoclonal antibody-specific immobilization of platelet antigens(MAIPA) assay,then expression of CD36 on monocyte was analysed by Monocyte Immuno uorescence Test-Flow Cytometry(MIFT) to classify the types of CD36 deficiency.Results 4 621 samples were screened,of which 191 were CD36 deficiency by PIFT and MAIPA assays.The incidence of CD36 deficiency was 4.13%(191 /4 621),while the incidence of Han ethnic population was 3.59%(109 /3 036),Zhuang was5.76%(80 /1 389),Yao was 2.38%(2 /84).117 of 191 CD36 deficiency donors were classified the types of CD36 deficiency.It showed that the overall proportion of type Ⅰ was 41.03%(48 /117),and Han ethnic population was 39.19%(29/74),Zhuang was 43.90%(18/41),Yao was 50%(1/2).while type Ⅱ was 58.97%(69/117),Han was 60.81%(45/74),Zhuang was 56.10%(23/41),Yao was 50%(1/2),respectively.Conclusion The incidence of CD36 deficiency of Guangxi population is 4.13%,while the proportion of type Ⅰ deficiency is 41.03%.Different ethnic groups are statistically significant differences on the structure of CD36 deficiency.The incidence of CD36 deficiency of Zhuang population was much higher than other nationality,which exhibit unique characteristics of Zhuang nationality.
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