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《Chinese Journal of Blood Transfusion》 2014-01
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Antibodies against major histocompatibility complex class Ⅰ-related chain A and organ transplantation

LIU Xi-aohua;DU Zhanhui;WU Zhenjun;JIAO Shuxian;Qingdao Blood Center,Institute of Blood Transfusion;  
MICA is a member of human MHC(major histocompatibility complex) class Ⅰ chain-related gene(MIC) family.MICA is a stress-induced antigen and acts as a cell surface ligand that can bind to the C-type lectin receptor(CLR) like activating receptor NKG2D,which is found on NK cells,CD8 T cells and γδ T cells.It is thougt that MICA combines with NKG2D which then regulates the function of immune effective cells.Recently,more and more attention is paid on the biological role of MICA in organ transplantation.A series of studies showed that anti-MICA could reduce the survival rates of kidney transplantation.In this article,we summarized the research progress on the polymorphism of MICA gene,the expression of MICA antigen,the antibodies against MICA,as well as the role of MICA in organ transplation.
【Fund】: 青岛市市南区科技发展计划资助项目(2009-5-21-GG);; 青岛市科技发展计划基金资助项目(10-3-1-9nsh)
【CateGory Index】: R392
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