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《Chinese Journal of Blood Transfusion》 2014-01
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The effects of CD40L in the side reactions of platelet transfusion

CHEN Qian;Hainan Blood Center;  
Platelet transfusions are commonly used treatments in modern transfusion medicine and occasionally lead to adverse reactions.In addition to their important functions in hemostasis and thrombosis,platelets' role in immunity and inflammation has become more evident.Recently,increasing evidence supports a key role of the interaction between CD40 ligand(CD40L) and CD40 in the pathogenesis of adverse transfusion reactions.In particular,CD40L as a platelet derived mediator appears to be a key factor promoting inflammatory processes.In this review,we will briefly summarize recent researches and developments on the role of CD40L in platelet transfusion reactions.
【CateGory Index】: R457.1
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【Co-citations】
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