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《Chinese Journal of Blood Transfusion》 2014-04
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The effects of adding saturated hydrogen gas to the platelets before platelet preservation

GU Haihui;ZHU Yanxia;HUA Meixian;GUO Huijun;CHA Zhanshan;ZANG Yang;Department of Transfusion,Changhai Hospital,Second Military Medical University;  
Objective To evaluate the effect of hydrogen gas(H2),a selective antioxidant,on platelet preservation.Methods Random donor concentrates(n = 12) and single donor platelets(n = 10) were collected and preserved by the standard methods.Aliquot each sample(40 mL each) for two platelet storage bags(20 mL each).H2was added to any one of aliquots before preservation.After 5 days of preservation at 22℃,check the value of platelet account(Plt),mean platelet volume(MPV),platelet distribute width(PDW),pH,glucose,lactate and CD62p in each platelet sample.Results After 5 days of preservation at 22℃,the pH value in both random donor concentrates(7.07 ± 0.15 vs 6.85 ± 0.34)(P 0.05) and single donor platelets(7.17 ± 0.26 vs 7.03 ± 0.35)(P 0.05)was significantly retained by the addition of hydrogen gas.The expression level of CD62p on platelets preserved with H2 was significantly lower than those preserved without H2(single donor concentrates:17.39 ± 2.88 vs 21.49 ± 4.2(P 0.01);random donor concentrates(17.84 ± 2.54 vs 21.73 ± 4.14)(P 0.01).Conclusion Hydrogen gas may play an effective role in preserving platelets by inhibiting the activation of platelets and maintain the pH value in the plasma.
【Fund】: 军队十二五重大项目(AWS11J007-05);; 长海医院“1255”学科建设计划(CH125531500)
【CateGory Index】: R457
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