Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Blood Transfusion》 2014-04
Add to Favorite Get Latest Update

The effects of adding saturated hydrogen gas to the platelets before platelet preservation

GU Haihui;ZHU Yanxia;HUA Meixian;GUO Huijun;CHA Zhanshan;ZANG Yang;Department of Transfusion,Changhai Hospital,Second Military Medical University;  
Objective To evaluate the effect of hydrogen gas(H2),a selective antioxidant,on platelet preservation.Methods Random donor concentrates(n = 12) and single donor platelets(n = 10) were collected and preserved by the standard methods.Aliquot each sample(40 mL each) for two platelet storage bags(20 mL each).H2was added to any one of aliquots before preservation.After 5 days of preservation at 22℃,check the value of platelet account(Plt),mean platelet volume(MPV),platelet distribute width(PDW),pH,glucose,lactate and CD62p in each platelet sample.Results After 5 days of preservation at 22℃,the pH value in both random donor concentrates(7.07 ± 0.15 vs 6.85 ± 0.34)(P 0.05) and single donor platelets(7.17 ± 0.26 vs 7.03 ± 0.35)(P 0.05)was significantly retained by the addition of hydrogen gas.The expression level of CD62p on platelets preserved with H2 was significantly lower than those preserved without H2(single donor concentrates:17.39 ± 2.88 vs 21.49 ± 4.2(P 0.01);random donor concentrates(17.84 ± 2.54 vs 21.73 ± 4.14)(P 0.01).Conclusion Hydrogen gas may play an effective role in preserving platelets by inhibiting the activation of platelets and maintain the pH value in the plasma.
【Fund】: 军队十二五重大项目(AWS11J007-05);; 长海医院“1255”学科建设计划(CH125531500)
【CateGory Index】: R457
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Lei Xiang, Li-Jie Huang, Lin Jia, Ya-Qian Liu, Yu-Qiong Zhao, Kai Wang, Animal Experiment Centers, PLA General Hospital, Beijing 100853, China Jing-Wang Tan, Jia-Hong Dong, Institute of Hepatobiliary Surgery, PLA General Hospital, Beijing 100853, China;Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine[J];世界胃肠病学杂志(英文版);2012-37
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 LIU Gang;JIANG Yu;CHEN Ying-xiao;University Town Hospital of Chongqing Medical University;Department of Infectious Diseases,The First Affiliated Hospital of Wenzhou Medical University;;Clinical Effect and the Mechanism of Oral Lactulose on Acute and Sub-acute Hepatic Failures[J];Health Medicine Research and Practice;2014-02
2 LIN Wendong;CANG Jing;FANG Fang;Department of Anesthesiology,Zhongshan Hospital,Fudan University;;Effect of Sevoflurane on Postoperative Neurocognitive Function:An Update[J];Chinese Journal of Clinical Medicine;2013-05
3 YAN Shu;WEI Xing;FENG Da-Ming;Institute of Cardiovascular Disease,Key Laboratory for Atherosclerology of Hunan Province,University of South China;;New Advances in the Mechanism of Prevention and Treatment of Myocardial Stunning[J];Chinese Journal of Arteriosclerosis;2013-12
4 SHI Hai-mei;ZHOU Hua-cheng;LIU Jin-feng;WANG Ya;CAO Jing-jing;JIA Ya-rui;Department of Pain,the Second Affiliated Hospital of Harbin Medical University,and the Hei Long Jiang Province Key Lab of Research on Anesthesiology and Critical Care Medicine;;The effect of hydrogen inhalation on shock and resuscitation induced-acute lung injury in rats[J];Journal of Clinical Anesthesiology;2014-05
5 WANG Wen-ying;CUI De-rong;JIANG wei;Department of Anesthesiology,the Sixth People's Hospital,Shanghai Jiao Tong University;;Advances of role of autophagy in cerebral ischemia-reperfusion injury[J];Journal of Shanghai Jiaotong University(Medical Science);2014-02
6 MI Zeng-fa;GAO You;YANG Xin-lei;MENG Hong-yang;GUO Zhi-qian;LEI Lei;JIANG Bi-chuan;ZHANG Xin-he;Burn and Plastic Department, No. 174 Hospital of PLA;;The Advance of Hydrogen Molecules in Medical Research[J];Medical Recapitulate;2013-19
7 Baoshan LI;Qu LIU;Qiang LI;Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy;Department of General Surgery, No. 254 Hospital of People's Liberation Army;;Protective effect of hydrogen-rich saline on liver mitochondrial injury in rats with ischemia-reperfusion[J];Chinese Journal of Clinical Oncology;2014-02
8 YU Shi-fang;LI Qiang;HONG Jun-ying;JIN Chen-hua;CHEN Bi-le;The First Affiliated Hospital of Wenzhou Medical University;;The targeted-regulating role of hsa-miR-326 on gene BCL2L1 and BAK1 by dual luciferase reporter system[J];Chinese Journal of Health Laboratory Technology;2014-08
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 GU Hai-hui,QIAN Bao-hua *, ZHANG Hao-xiang,WU Jiang,WANG Xuan, HUA Mei-xian, GUO Feng (Department of Blood Transfusion,Changhai Hospital , Second Military Medical University,Shanghai 200433,China);Mixture of low concentration dimthyl sulfoxide and second-messenger effector as cryopreserving solution in protection of platelets activity[J];Academic Journal of Second Military Medical University;2005-04
2 GU Hai-hui,QIAN Bao-hua,SONG Yun,et al.Department of Blood Transfusion,Changhai Hospital,Second Military Medical University,Shanghai 200433;Recovery of Platelet Count of Platelet Concentrates Following Cryopreservation with Various Doses of Second-messenger Effectors and 2% Dimethyl Sulfoxide as Cryopreserving Solution[J];Journal of Clinical Transfusion and Laboratory Medicine;2006-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved