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《Chinese Journal of Blood Transfusion》 2014-04
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HBV serological characteristics in HBsAg screening reactive blood donors in Shenzhen

GU Xinghui;YE Xianling;DU Peng;XIONG Wen;LIU Heng;WANG Songxing;WU Lingfeng;Shenzhen Blood Center;Southern Medical University;  
Objective Five makers of hepatitis B,neutralization test and HBV-DNA detection were carried out in the HBsAg screening positive blood samples from December 2012 to May 2013 to understand the hepatitis B infection status and serological characteristics in those blood donors.Methods Screening model was chose as 1 time ELISA and 1 time NAT.The samples with HBsAg positive results were detected by neutralization test,anti-HBs test,anti-HBeAg test,anti-HBe test,anti-HBc test,as well as a quantitative detection of HBsAg and anti-HBs at the same time.Results In the voluntary blood donos,the positive rate of HBsAg detected by ELISA was 0.63%(236 /37 669);mainly with serological patterns of HBsAg(+),anti-HBe(+),and anti-HBc(+),accounting for 73.31%.There were no statistical differences(χ2= 8.40,P 0.05) in constituent ratio of serological pattern between NAT positive and negative group.A significant difference was found(χ2= 47.58,P 0.01) in different HBsAg concentration groups in NAT positive samples.NAT positive rate was 100% when the HBsAg concentration was higher than 100 IU / mL.Between NAT positive and negative groups,no statistical differences(χ2= 1.39,P 0.05) were showed in the HBsAg and anti-HBs coexistence model.Conclusion HBsAg(+),anti-HBe(+),anti-HBc(+) were the mainly serological patterns of HBsAg screening positive results in blood donors,and the concentration of HBsAg showed some correlation with NAT positive rate.
【CateGory Index】: R446.6
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