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《Chinese Journal of Blood Transfusion》 2014-04
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A follow-up study on one round ELISA reactive donors in Nanning

PANG Dong;SHEN Weidong;ZHENG Hui;QIU Changwen;SU Wujin;LIANG Yian;CHEN Yue;HUANG Jinhuan;NONG Yuan;Central Blood Station in Nanning;  
Objective To evaluate the one round ELISA screening reactive blood donors who is truly infected;and to make suggestions for blood donor calling back strategies.Methods After deferral for 6 months because of ELISA screening reactive,the donors were call back for sampling again with following 3 balance tests:dual ELISA screening,nucleic acid testing(NAT) and related confirmatory test.Results Among 119 cases of blood donors tracking,a) 1 sample was ELISA positive for double reagents and 15 samples were positive for single reagent;b) 1 sample was positive for NAT detection;c) HBsAg neutralization test were all negative;1 sample was positive for anti-HCV restructuring immune imprinted test(RIBA),and inconclusive for 2;anti-HIV western blot(WB) test were all negative;TP antibodies against Treponema pallidum(TPPA) tests were negative.Conclusion The most initial one round ELISA reactive blood donors are false positive,which indicates that plenty of the deferred donors are potentially suitable for donation.Our present policies for blood screening and deferral strategies are worth further consideration.Thus,we suggest to amending some supplements to the policy with adding confirmatory test in routine screening and implementing the calling back criteria for blood donors,so as to reduce the donor lost and ensure the blood safety.
【Fund】: 广西壮族自治区卫生厅科研课题(Z2013729)
【CateGory Index】: R446.6
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