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《Chinese Journal of Blood Transfusion》 2014-04
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Characteristics of panel reactive antibodies in patients waiting for kidney transplantation and analysis of sensitization factors

WENG Meizhi;SUN Yu;WU Hong;XIAO Li;XIONG Li;LI Guoliang;Jiangxi Blood Center;  
Objective To investigate the characteristics of panel reactive antibodies(PRA) and the sensitization factors in patients waiting for kidney transplantation.Methods PRA tests were performed by the method of ELISA and 1618 patients waiting for kidney transplantation were tested.Patients were divided into five groups,according to their history of transfusion,pregnancy and transplantation.Group A:804 patients with neither transfusion nor pregnancy history;group B:330 patients with mere transfusion history;group C:229 patients with mere pregnant history;group D:196 patients with both transfusion and pregnant history;group E:59 patients with transplantation history.Results PRA positive rate was 5.97%,18.18%,22.71%,48.47% and 76.27% in group A,group B,group C,group D and group E respectively.Some antibodies of human leukocyte antigen(HLA) had higher frequency,including antibodies such as HLA-A2,A23,A66,B7,DR52,DR53,DQ5 and DQ6.The antibodies of DR52 and DR53 had a high frequency in the patients with transplantation history and the frequency was 19.32% of the total HLA-Ⅱ antibodies.Conclusion Different individuals with the same allergenic factors had different sensitivity;with the same allergenic factors,the PRA positive rate of male and female patients had not significantly differenc;Transfusion,pregnancy and transplantation had synergy effect and could increase the sensitization rate together;Antibody frequencies and the distributions of antigens were not consistent;The production of DR52 and DR53 antibodies had a certain relevance with the graft dysfunction.
【CateGory Index】: R446.6;R692.5
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Chinese Journal Full-text Database 3 Hits
1 Wu Jun-jie, Jia Bao-xiang, Tian Ye Department of Kidney Transplantation, Beijing Friendship Hospital, Capital Medical University Beijing 100050, China;Analysis of factors inducing panel reactive antibodies in patients waiting for first kidney transplantation[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2011-44
2 LI Liuyang, LIN Minzhuan. Medical Department of Hemopurification and Renal Transplantation, Zhujiang Hospital, First Military University, Guangzhou 510282, China;A study of HLA matching in sensitized recipients of renal transplantation[J];CHINEAE JOURNAL OF ORGAN TRANSPLANTATION;2000-04
3 ZENG Wen-tao1,FU Qian2,LIU Long-shan1,WANG Chang-xi2(1.Dept of Surgery Laboratory,The First Affiliated Hospital of Zhongshan University,Guangzhou 510080,China;2.Transplantation Dept,The First Affiliated Hospital of Zhongshan University,Guangzhou 510080,China);Characteristics of anti-HLA antibodies in uremic patients and analysis of sensitization factors[J];Chinese Journal of Health Laboratory Technology;2010-08
Chinese Journal Full-text Database 10 Hits
1 XUE Min~1,WANG Chengya~2,Kukuruga D~3,et al.1 Blood Center of Jiangsu Province,Nanjing 210029,China;2 HLA Laboratory,the First Subsidiary Hospital of Nanjing Medical University;3 National Laboratory of Histocompatibility,American Red Cross,USA;Identification of a novel HLA allele (B~*0740) by sequencing-based typing[J];Chinese Journal of Blood Transfusion;2005-05
2 LI Changying~1,ZHAO Lin~1,LI Jianzhong~2,WU Zhenjun~1,LI Xiaofei~2,JIAO Shuxian~1.1 Qingdao Center Blood Station,Qingdao 266071, China;2 Qingdao Infectious disease Hospital,Qingdao 266033,China;The relationship between HLA class Ⅰ,Ⅱ alleles and HBV Infection in Northern Chinese[J];Chinese Journal of Blood Transfusion;2005-06
3 LIU Mengli, LIU Sheng, ZHANG Yan, YE Shihui, QI Jun , WEI Xiaoqian. Blood Center of Shaanxi Province, Xi'an Shaanxi 710061, China;Identification of a novel HLA-A~*0290 allele by sequencing-based typing[J];Chinese Journal of Blood Transfusion;2006-04
4 LIU Jie,ZHANG Chunyan,HOU Ling,et al.Heilongjiang Blood Center,Harebin 150056,China;The distribution of HLA allele and haplotype in Heilongjiang Chinese Han unrelated blood stem cell donors[J];Chinese Journal of Blood Transfusion;2009-03
5 CHEN lin,JIAO lixin,REN haibo,et al.(JiLin province Blood Center,Jilin Changchun 130033);The frequencies of HLA-A、B、DRB1 allels and Haplotype and their distribution among haemopoietic stem cell of Han volunteers in Jilin bone marrow library of China[J];Chinese Journal of Blood Transfusion;2010-01
6 Liang Xiaolan,Yang Conglin,Wan Changchun,et al.Chinese Academy of Medical Sciences,Institute of Hematology,Tianjin Cord Blood Bank(Tianjin,300020);ASSOCIATION OF HLA-ALLELES WITH ACUTE LYMPHOBLASTIC LEUKEMIA[J];Journal of Leukemia & Lymphoma;2004-01
7 MAO Wei,HUANG Xia,WANG Rong-gan,et al.(Chongqing Blood Center,Chongqing 400015,China);Study on genetic polymorphism of HLA-A,B,DRB1 allele in Chongqing population[J];Chongqing Medicine;2006-14
8 WANG Shu-long,ZHANG Gen-fu,HUANG Chi-bing(1.Department of Urology,Hubei Provincial Corps of Chinese People′s Armed Police Forces,Wuhan 430061,China;2.Department of Kidney Transplantation,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Evaluation of the effect of PRA matching in sensitized recipients of renal transplantation[J];Chongqing Medicine;2006-16
9 GUAN Lin-mei1,CAI Peng2,WANG Yan1,YU Wei-jian3(1.Department of Laboratory Medicine,Dalian Municipal Friendship Hospital,Dalian 116001,China;2.Department of Laboratory Medicine,Liaoning International Travel Healthcare Center,Dalian 116001,China;3.Dalian Red Cross Blood Center,Dalian 116001,China);Correlation analysis between chronic glomerulonephritis uremia and HLA-DRB1 in Han in Dalian[J];Journal of Dalian Medical University;2011-06
10 SHEN Chun-Mei1,2,3, ZHU Bo-Feng1,3,4, LIU Meng-Li2, ZHANG Hua-Dong1,3, LI Sheng-Bin1,3,4 1Key Laboratory of Ministry of Health for Forensic Sciences, Xi'an Jiaotong University, Xi'an 710061, China,2Blood Center of Shaanxi Province, Xi'an 710061, China,3Key Laboratory of Environment and Gene Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an 710061, China,4Department of Forensic Medicine, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China;HLA-A, B, and DRB1 genes and haplotype polymorphisms in Hui nationality group of Ningxia Hui autonomous region in China[J];Journal of the Fourth Military Medical University;2008-17
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Hong 1 , ZHAO Xiao-bing 2 , WU Da-lin 11 Central Laboratory, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China; 2 Department of Hematology, General Hospital of Lanzhou Command, Lanzhou 730050, China;Detection of panel-reactive antibody before and after renal transplantation:analysis of641cases[J];Journal of First Military Medical University;2003-08
2 HUANG Xian-en1, FAN Li-pei1, LI Liu-yang1, ZHAO Ming1, XIA Sui-sheng21Department of Organ Transplantation, Zhujing Hospital, Southern Medical University, Guangzhou 510282, China; 2Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Risk factors of acute rejection in sensitized kidney transplant recipients[J];Journal of First Military Medical University;2004-10
3 Ma Hongjing, Xiao Lulu, Guo Kunyuan, et al. Department of Hematology, Zhujiang Hospital, Nanfang Medical University, Guangzhou 510282;Analysis of HLA-A, B, DRB1 allele frequencies in Guangdong Han population[J];Guangdong Medical Journal;2005-03
4 ZHANG Aimin~1 LI Xiangtie~1 LI Shenqing~1 XU Youhe~1 LIU Shaoge~1 LIU Yangdong~1 WANG Xulei~1(~1Department of Urology,General Hospital of Jina Command of PLA,Jina,250031,China);Analysis of contributing factors in renal transplant recipients with high pannel reactive anti HLA antibodies(PRA)[J];Journal of Clinical Urology;2006-03
5 Li Xiaobei1,2, Ishida Hideki2, Furusawa Miyuki2, Toki Daisuke2, Iida Shouichi2,Yamaguchi Yutaka3, Tanabe Kazunari2(1. Department of Urology, Beijing Chaoyang Hospital, Capital Medical University; 2. Kidney Center,Tokyo Women’s Medical University; 3. Department of Pathology, Tokyo Jikei University);High Incidence of Humoral Rejection in Living Donor Renal Transplant Recipients with Anti-HLA Antibodies[J];Journal of Capital Medical University;2008-02
6 Jia Bao-xiang,Wu Jun-jie,Tian Ye Affiliated Beijing Friendship Hospital,Capital University of Medical Sciences,Beijing 100050,China;Relationship between panel reactive antibody level and renal acute rejection[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-53
7 Li Liuyang; Gao Wei; Wang Xiwen. (Department of Hemopurification and Renal Transplantation, Zhujiang Hosital, The First Military Medical University, Guangzhou 510282);Prediction of sensitization for recipients of renal transplant and its clinical implication[J];CHINEAE JOURNAL OF ORGAN TRANSPLANTATION;1997-04
8 XIAO Jiaquan,TANG Xiaoda,WANG Xianghui,et al. Renal Transplant Center, Shanghai First People's Hospital, Shanghai 200080,China;Detection of sensitization to HLA antigens in long term renal transplant recipients and its clinical implication[J];CHINEAE JOURNAL OF ORGAN TRANSPLANTATION;2000-03
9 Xiao Lulu, Zhang Sheng, Ye Xin, et al. Guangzhou Tissue Typing Centre, Guangzhou 510095;The detection and relevance of DTT-FRA in highly sensitized renal recipients[J];Chinese Journal of Nephrology;1997-05
10 FU Qian,WANG Chang-Xi,ZENG Wen-Tao,CHEN Li-Zhong.The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510080,China;Preoperative Screening for specific antibodies against human leukocyte antigens in sera of the recipients of renal transplantation (3500 cases)[J];Chinese Journal of Immunology;2009-02
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