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《Chinese Journal of Blood Transfusion》 2014-04
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Characteristics of panel reactive antibodies in patients waiting for kidney transplantation and analysis of sensitization factors

WENG Meizhi;SUN Yu;WU Hong;XIAO Li;XIONG Li;LI Guoliang;Jiangxi Blood Center;  
Objective To investigate the characteristics of panel reactive antibodies(PRA) and the sensitization factors in patients waiting for kidney transplantation.Methods PRA tests were performed by the method of ELISA and 1618 patients waiting for kidney transplantation were tested.Patients were divided into five groups,according to their history of transfusion,pregnancy and transplantation.Group A:804 patients with neither transfusion nor pregnancy history;group B:330 patients with mere transfusion history;group C:229 patients with mere pregnant history;group D:196 patients with both transfusion and pregnant history;group E:59 patients with transplantation history.Results PRA positive rate was 5.97%,18.18%,22.71%,48.47% and 76.27% in group A,group B,group C,group D and group E respectively.Some antibodies of human leukocyte antigen(HLA) had higher frequency,including antibodies such as HLA-A2,A23,A66,B7,DR52,DR53,DQ5 and DQ6.The antibodies of DR52 and DR53 had a high frequency in the patients with transplantation history and the frequency was 19.32% of the total HLA-Ⅱ antibodies.Conclusion Different individuals with the same allergenic factors had different sensitivity;with the same allergenic factors,the PRA positive rate of male and female patients had not significantly differenc;Transfusion,pregnancy and transplantation had synergy effect and could increase the sensitization rate together;Antibody frequencies and the distributions of antigens were not consistent;The production of DR52 and DR53 antibodies had a certain relevance with the graft dysfunction.
【CateGory Index】: R446.6;R692.5
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