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《Chinese Journal of Blood Transfusion》 2014-04
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Probability analysis of irregular antibody

LI Xiaohong;HUANG Xia;CHENG Lei;TAN Xixi;MAO Wei;Chongqing Blood Center;  
Objective To analyze the probability of irregular antibody identification.Methods Fisher's exact test of four-told table data is used.The probability level of irregular antibody identification is listed in tables.Results Take 10-cell panel for example:1) 95% probability level can't be reached if only 1 cell's antigen is positive or negative,even if the spectrum of serum is fully consistent with the pattern table of the panel.The antibody specificity should be further identified.95% probability level can be reached if the antigen of 2 ~ 8 cells is positive;2) 6 cells(3 positive /3 negative) or 7 cells(2 positive /5 negative or 5 positive /2 negative) are at least needed if some cells must be selected for insufficient serum;3) when there are 4 ~ 7 cells with an antigen,1 cell with false negative response is accepted if dosage effect exists in antigen and antibody.Conclusion To know all kinds of probability level of the irregular antibody identification and its calculation methods could ensure safe transfusion and reduce errors when the antibody specificity is reported.
【Fund】: 重庆市卫生局科研课题(2011-2-406)
【CateGory Index】: R446.6
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