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《Chinese Journal of Blood Transfusion》 2014-04
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Factors influencing transfusion in patients with allogeneic peripheral blood stem cells transplantation:a retrospective study

ZHUANG Yuan;PAN Jichun;WANG Haibao;WANG Deqing;Department of Blood Transfusion,the Chinese PLA General Hospital;  
Objective To explore the influencing factors on transfusion by a retrospective study with patients undergoing allo-PBSCT.Methods 85 patients undergoing allo-PBSCT were enrolled at the Chinese PLA General Hospital between January 2009 and December 2011.Multivariable logistic regression analysis was used to analyze the influencing factors on transfusion(the amount of red blood cells and platelets infused) in the patients undergoing transplantation.Results The Results showed that the average amount of red blood cell transfused in the patients peri-transplantation was 8.36 ± 8.24 U,and average amount of platelet transfused was 11.95 ± 8.1 U.Of 85 patients,40% infused red blood cells no less than 8.5 U。Platelet recovery time after transplantation,marrow function status before pretreatment(P 0.01),HLA matching and body surface area(P 0.05) were associated with greater likelihood of more red blood cell infusion.40% patients infused platelets no less than 12 U,which were affected by platelet recovery time,HLA matching(P 0.01),donor-recipient ABO incompatibility and age(P 0.05).The amount of infused RBC and platelet during the peri-transplantation period was respectively 11.31 ± 14.16 U and 15.13 ± 10.01 U in major ABO incompatibility recipients,which was higher than the compatibility recipients(P 0.05).In patients whose marrow function status was poor before pretreatment,the amount of infused RBC was 13.22 ± 11.89 U,much higher than patients with relatively normal marrow function(P 0.05).Conclusion It is concluded that platelet recovery time and HLA matching can greatly affect the amount of red blood cell and platelet transfused,donor-recipient ABO incompatibility can affect the amount of platelet transfused and marrow function status before pretreatment can affect the amount of RBC transfused in this study.
【Fund】: 2010年卫生部行业专项(201002005)
【CateGory Index】: R457.7
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1 ZHANG Jing-wen;LI Xu-dong;ZENG Yun-xin;WANG Yi;CHEN Yu-xin;LIN Dong-jun;The Third Affiliated Hospital of Sun Yat-sen University,Sun Yat-sen Institute of Hematology;;Impact of ABO incompatibility on allogeneic peripheral blood stem cell transplantation in leukemia patients[J];Journal of Tropical Medicine;2013-10
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