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《Chinese Journal of Blood Transfusion》 2014-04
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The correlation between IgG anti-A/B titers by the gel test and hemolytic disease of the newborn

ZHANG Min;LU Huixia;XIN Qi;LIANG Lushi;Department of Blood Transfusion,Zhongda Hospital Affiliated to Southeast University;  
Objective To explore the correlation between IgG anti-A /B titers by the gel test and hemolytic disease of the newborn.Methods Detect IgG anti-A / B titers of 443 blood group O pregnant who is ABO-incompatible by the gel test.Observe the distribution of IgG anti-A / B titers among them and to explore the correlation between IgG anti-A / B titers and hemolytic disease of the newborn.Results In general,28 of 443 births are ABO hemolytic disease.Morbidity of ABO hemolytic disease in the newborn is 6.32%.None of the newborns with maternal IgG anti-A / B titers ≤28 have ABO hemolytic disease.All of the hemolytic newborn infants with maternal IgG anti-A / B titers between 256 and 2 048.Morbidity rise up with the increasing of IgG anti-A /B titers.The incidence of the disease was increased significantly when IgG anti-A /B titers of maternal ≥512 or IgG anti-AB titers ≥256,P 0.05.There is no significant correlation between morbidity of ABO hemolytic disease and the number of pregnancies.There is no correlation between IgG anti-A /B titers and the number of pregnancies.It is possible that ABO hemolytic disease could be found in the first newborn of the female.Conclusion Morbidity of ABO hemolytic disease rise up with the increasing of IgG anti-A /B titers.It is possible that newborn infants with maternal IgG anti-A /B titers≥256 could lead to ABO hemolytic disease.Doctors should pay attention to them.Newborns with maternal IgG anti-A/B titers≥512 have a greater chance for ABO hemolytic disease.
【CateGory Index】: R446.6;R722.1
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