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《Chinese Journal of Blood Transfusion》 2014-04
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Retrospective analysis and coping measures of poor deaggregation of in vitro apheresis platelets

NIU Changlin;DONG Jinying;ZHANG Meiping;Blood Center of Puyang;  
Objective To investigate the causes of poor deaggregation of in vitro apheresis platelets and its coping measures,to ensure the normal physiological activity of platelets and the clinical infusion effect.Methods During March 2011 to February 2013,poor deaggregation of in vitro apheresis platelets was statistical analyzed.The effect of adding a proper amount of anticoagulants into platelet products on deaggregation was analyzed.Results Poor deaggregation of apheresis platelets appeared in 38 donors,including 2 repeat donors who had poor deaggregation in each donation,more than 20 repeat donors who had one poor deaggregation and 16 first time donors.Adding a proper amount of anticoagulant could effectively improve deaggregation.Conclusion Poor deaggregation of apheresis platelet can occur in the first time donors and repeat donors.Factors related to donors account for the highest proportion of factors associated with poor deaggregation.Targeted measures can effectively reduce the occurrence of poor deaggregation.When platelet poor deaggregation happens,adding a proper amount of anticoagulant can promptly improve it and ensure the clinical effect of platelet.
【CateGory Index】: R457.1
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