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《Chinese Journal of Blood Transfusion》 2014-06
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Association between single nucleotide polymorphisms and non-small cell lung cancer in Chinese population: a casecontrol study

LI Ying;REN Fan;FAN Yaguang;LI Yongwen;LIU Hongyu;CHEN Jun;Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment; Tianjin Lung Cancer Institute; Tianjin Medical University General Hospital;Department of Lung Cancer Surgery,Tianjin Medical University General Hospital;  
Objective To evaluate the role of STAT6 rs1059513,IL-13 rs20541 and IL-4R rs1801275 single nucleotide polymorphisms( SNPs) as risk factors in non-small cell lung cancer patients. Methods A total of 468 healthy controls and262 cases of primary lung cancer patients were recruited for this study. Genotypes were determined by using Taqman technology. Results The genotypes frequencies of STAT6 rs1059513 in case group were TT 83. 6%,CT 16. 4%,CT + CC 16. 4%,and in control group were TT85. 9%,CT 13. 9%,CT + CC 14. 1%,respectively. The genotypes frequencies of IL13 rs20541in case group were CC 7. 63%,CT + TT 92. 4%,and in control group were CC 8. 12%,CT + TT 91. 6%,respectively. The genotypes frequencies of IL4R rs1801275 in case group were AA 65. 6%,A /G + GG 34. 4%,and in control group were AA68. 8%,A /G + GG 31. 2%,respectively. The distribution of polymorphism frequencies in the case group and the control group were P 0. 05. Conclusion There was no statistically significant association between the case group and the control group for all the genotypes above.
【Fund】: 国家自然科学基金(81172233 81372306);; 天津市科技支撑项目(12ZCDZSY16100);; 天津市自然科学基金重点项目(12JCZDJC24400);天津市自然科学基金面上项目(13JCYBJC22600);; 教育部新世纪人才基金(NCET-10-0956)的资助
【CateGory Index】: R734.2
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