Study on a GATA-1 motif of Duffy gene promoter in Chinese population
SU Yuqing;LIANG Yanlian;ZHANG Yinze;WU Fan;Shenzhen Blood Center;
Objective To study the characterization of the GATA-1 box in promoter region of the Duffy blood group gene among Chinese population. Methods A total of 182 blood samples from unrelated blood donors were phenotyped for Duffy blood group by the antiglobulin gel test,and genotypes were detected by PCR-SSP. The GATA-1 boxes in the Duffy gene promoter were also sequenced. Results In 182 donors,153 were Fy( a + b-),26 Fy( a + b +),2 Fy( a- b +),and no Fy( a- b-) were found. The serologically determined phenotypes were consistent with genotypes by PCR-SSP. 46T /T was observed in the GATA-1 box of Duffy blood group gene promoters in all samples. One case with phenotype Fy( a + b-) has a ntC-108T heterozygous mutation in the promoter. Conclusion The binding site of GATA-1 all were wild type among Chinese individuals in this study. A novel allele( ntC-108T) of Duffy blood group gene was identified.
【CateGory Index】：
R457.11
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SU Yuqing1,Chen Xiaoming2,LIANG Yanlian1,ZHANG Yinze1,ZHOU Dan1,LI Dacheng1.1.Shenzhen Blood Center,Shenzhen 518035,China;2.Anqing Municipal Hospital;Polymorphism of Duffy blood group gene in Shenzhen blood donors[J];Chinese Journal of Blood Transfusion;2013-04 |
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SU Yuqing1,Chen Xiaoming2,LIANG Yanlian1,ZHANG Yinze1,ZHOU Dan1,LI Dacheng1.1.Shenzhen Blood Center,Shenzhen 518035,China;2.Anqing Municipal Hospital;Polymorphism of Duffy blood group gene in Shenzhen blood donors[J];Chinese Journal of Blood Transfusion;2013-04 |
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YU Lin;CHEN Wenzhu;FENG Jing;ZHU Kai;WANG Haijuan;CHEN Jian;Sichuan University West China Second Hospital Clinical laboratory;;The identification test on rare autoantibodies combined with anti-Fy~b from a case of patient' and blood transfusion therapy of the patient[J];Chinese Journal of Blood Transfusion;2014-01 |
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SI Xiao-hui1,YAO Yong-fang1,ZHANG Shuan-ling1,LIU Wei1,ZHOU Liang2,XU Huai-liang1(1.College of Animal Science and Technology,Sichuan Agricultural University,Ya'an,Sichuan Province 625014,China;2.Institute of Laboratory Animals Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital,Chengdu 610212,China);Cloning and Sequence Analysis of Duffy Antigen/Receptor for Chemokines Gene in Macaca thibetana[J];Sichuan Journal of Zoology;2012-04 |
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Ebrahim Miri-Moghaddam;Zakaria Bameri;Mehdi Mohamadi;Genetics of Non-Communicable Disease Research Centre,Zahedan University of Medical Sciences;Department of Genetics,Zahedan University of Medical Sciences;Infections and Tropical Research Center,Zahedan University of Medical Sciences;Health Promotion Research Center,Zahedan University of Medical Sciences;;Duffy blood group genotypes among malaria Plasmodium vivax patients of Baoulch population in southeastern Iran[J];亚太热带医药杂志(英文版);2014-03 |
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LIU Xiao-feng,OU Zhou-luo,SHAO Zhi-min(Department of Breast Surgery,Cancer Hospital,Fudan University,and Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China);Polymorphism of Duffy blood group phenotypes and breast cancer in Chinese female breast disease patients of Han population[J];China Oncology;2007-12 |
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