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《Chinese Journal of Blood Transfusion》 2014-06
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Analysis of the factors influencing the efficacy of platelet transfusion

CAO Yuezhen;ZHANG Qi;WANG Yuan;WU Yubo;XIA Rong;Department of Transfusion,Huashan Hospital of Fudan University;  
Objective To determine the factors inflecting the efficacy of platelet transfusions. Methods After transfusing platelet to 256 cases of thrombocytopenia,solid-phase agglutination method was adopted to improve the platelet antibody screening. 1 h and 24 h increased platelet recovery( PPR) and platelet count index( CCI) were the criterion to decide whether platelet transfusion was effective. And the 98 cases of patients whose platelet transfusion effect was not ideal had been studied for root causes,in order to obtain the factors of platelet transfusion refractoriness( PTR). Results The ratio of PTR was38. 3%( 98 /256),while the male cases was 32. 2%( 39 /121),the female cases was 43. 7%( 59 /135) [the females who had history of pregnancy was 59. 3%( 35 /59) ],the overweight patients( 25≤BMI≤29. 9) was 42. 9%( 33 /77),the multiple platelet transfusion patients( 3 or higher) was 53. 8%( 35 /65),the patients between 41 year old and 70 year old was58. 2%( 57 /98),the platelet antibody( +) cases was 27. 6%( 27 /98),the platelet antibody(-) cases was 71. 4%( 71 /98),which included35. 2%( 25 /71) of infection and 33. 8%( 24 /71) of fever. Conclusion Platelet count has been increased obviously after the first platelet transfusion,and blood coagulation function has been improved effectively. But the improvement of patients with multiple platelet transfusion( 3 or higher) is not obvious. The main factors of PTR are non-immunologic factors,in which the infection and fever represent significant shares,and platelet antibody is an important immune factor affecting the efficacy of platelet transfusion. PTR is increases along with the age and weight increasing. The PTR of females is higher than that of others especially who has a history of pregnancy.
【Fund】: 国家自然科学基金面上项目(81170530);; 上海市自然科学基金面上项目(11ZR1405200)
【CateGory Index】: R457.1
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