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《Chinese Journal of Blood Transfusion》 2014-06
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Influence of multiple factors on positive panel reactive antibodies in patients waiting for kidney transplantation

XUE Hao;ZHANG Zhimei;ZHANG Hong;CAO Qiong;Nanfang Hospital,Southern Medical University;  
Objective To explore the influence of multiple factors on positive panel reactive antibodie( PRA) in patients with ESRD waiting kidney transplantation. Methods ELISA was used to detect the serological PRA in patients waiting for kidney transplantation from Guangzhou Nanfang Hospital. Age,sex,transfusion,transplant and pregnancy were assumed as the potential risks to explore association with positive PRA using logistic regression. Results The risk of females were 5. 591times of males( OR 95% CI: 3. 148 ~ 9. 931); that of transfusion recipients were 2. 692 times of non-transfusion recipients( OR 95% CI:1.543 ~4.699); the risk of 5.059 was showed in transplanted patients vs. non-transplant ones( OR 95% CI:2. 265 ~ 11. 299). There were no significant associations between the positive PRA in both age and pregnancy( P 0. 05).Conclusion Sex and transfusion were independent influencing factors of sensitization of PRA. There was no statistically significant association between age and pregnancy. The impact of history of transplant on PRA needs to be further studied.
【CateGory Index】: R699.2
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