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《Chinese Journal of Blood Transfusion》 2014-06
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The comparison of HCV subtypes between clinical patients and blood donors in Guangdong Province,China

RONG Xia;ZHENG Ying;XIONG Huaping;XU Ru;HUANG Jieting;WANG Ming;HUANG Ke;LIAO Qiao;FU Yongshui;Guangzhou Blood Center;The 3rd affiliated Hospital of Southern Medical University;  
Objective To investigate the prevalence of HCV subtypes in clinical patients and blood donors in Guangdong province,China. Methods 191 samples of clinical patients and 222 samples of blood donors whose HCV RNA were positive were collected from Guangdong area. HCV E1 gene was amplified by RT-nested PCR and then sequenced on both directions. HCV subtypes were assigned by constructing phylogenetic trees with MEGA5 software. Moreover,SPSS16. 0 software was applied to compare the difference between these two groups. Results Of 191 clinical patients,HCV genotype1a,1b,2a,3a,3b,6a and 6n was 1. 05%( 2 /191),66. 49%( 127 /191),8. 90%( 17 /191),2. 62%( 5 /191),2. 62%( 5 /191),17. 80%( 34 /191) and 0. 52%( 1 /191),respectively. Of 222 blood donors,HCV genotype 1a,1b,2a,3a,3b,6a and 6n was0. 45%( 1 /222),41. 44%( 92 /222),6. 76%( 15 /222),8. 56%( 19 /222),4. 95%( 11 /222),37. 39%( 83 /222) and0. 45%( 1 /222),respectively. The proportion of HCV-1b was higher in clinical patients than in blood donors( P 0. 01),while the proportion of 3a and 6a subtypes were higher in blood donors than in clinical patients( P 0. 05 and 0. 01).Conclusion In Guangdong province,HCV-1b and 6a remained the predominant subtypes in clinical patients and blood donors. The proportion of HCV-1b,3a and 6a subtypes are significantly different between clinical patients and blood donors.
【Fund】: 国家自然科学基金(81273145);; 广东省自然科学基金(S2013010015459);; 广州市卫生科技重大项目(20141A031001)
【CateGory Index】: R512.63;R440
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