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《Chinese Journal of Blood Transfusion》 2014-06
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The analysis of the polymorphism of human platelet antigen genes in Han population,Guizhou,China

YIN Hong;YANG Jinyu;YANG Fang;ZENG Xiaojing;ZHONG Nana;Inspection Department,Guiyang Medical College;Central Hospital of Xiaozhaiba;  
Objective To investigate the characteristics of distribution of HPA-1 ~ 5,15 gene polymorphism of Guizhou Han population,and to provide reference data for the prevention and control of HPA autoimmune disease,and the establishment of the genotyping library in Guiyang. Methods By adopting the method of PCR-SSP to 700 unrelatedhealthy blood donors for HPA-1 ~ 5,15 systems genotyping. The gene frequency and genotype were calculated,and the polymorphism distribution was summed up,and the difference with other populations were compared,in order to clarify the region characteristics.Results All systems were polymorphism distribution. HPA-1 and-4 close to aa single genotype distribution; HPA-2 and-5have a small amount of hybrid,ab heterozygote followed by 64 and 30 cases,there are 4 cases-2 bb; HPA-3 and 15 highly heterozygous,aa genotype respectively 242 and 210,ab in order for 347 and 350,and there are more bb genotype,turn for 111and 140 cases. The differences between other regions and countries increased with regional and ethnic differences. Conclusion The HPA-1 ~ 5,15 system genes of Guizhou province Han population were polymorphism distribution. a and b of HPA-15,3,2 and 5 gene hybrid rate is higher,which should been given more attention in the clinical prevention and control of HPA autoimmune diseases.
【Fund】: 贵州省科委资助基金(No.E2009-17)
【CateGory Index】: R392.7
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