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《Chinese Journal of Blood Transfusion》 2016-01
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Confirmatory strategy for anti-HCV screening-reactive donors

YANG Tao;NIU Libin;LI Ling;ZAO Yungang;JIA Huiqin;HAO Yaqin;WANG Hongmei;ZHANG Xumin;CUI Yunkang;LI Ze;Changzhi Blood Station;Institute of Transfusion Peking Union Medical College,Chinese Academy of Medical Sciences;  
Objective To confirm the blood donors who were anti-HCV screening-reactive by ELISA,and to establish a confirmatory strategy. Methods From December 2013 to September 2015,samples from blood donors who were screened reactive on anti-HCV by ELISA,re-tested by ELISA and ID-NAT were collected. Then,donors were anti-HCV positive or false positive were identified by follow-up. Reorganization of the Western blot test( RIBA) was conducted. Results A total of 73 donors were enrolled in this study based on the criterion that they were screened reactive by ELISA. The samples were tested by ELISA and ID-NAT. From follow-up,43 donors who completed the study could be classified into three categories for HCV status: 8( 18. 6%) true-positive,33( 76. 7%) false-positive and 2( 4. 7%) indeterminate. Data on 30 donors were withdrawn due to loss from follow-up. 10. 9% of blood donors were true positives on the anti-HCV antibody test. Conclusion If test results for anti-HCV ELISA and ID-NAT are both reactive,the end result was determined to be positive. If only ELISA is reactive and RIBA is positive,the end result was determined to be positive. If only ELISA is reactive and RI-BA is negative or indeterminate, the end results should be followed up after three months. Thus far,we did not find a donorwho was tested ID-NAT reactive and ELISA non-reactive. The exact method of follow-up is unclear,and further studies are needed.
【CateGory Index】: R446.6
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