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《Chinese Journal of Blood Transfusion》 2016-01
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Effect of-35kb T/C polymorphism located in HLA-C gene 5'UTR on HIV progression

OU Guojin;WANG Jue;LIU Honglu;JI Xin;QIN Gungming;WANG Chunyan;TANG Dabin;CHEN Qiang;LIU Zhong;Institute of Blood Transfusion,Chinese Academy of Medical Sciences & Peking Union Medical College;Sichuan Provincial Center for Disease Control and Prevention;Sichuan Umbilical Cord Blood Bank;  
Objective To investigate the role of HLA-C-35 kb C / T polymorphism among HIV infected progressors,HIV infected long-term non-progressors and healthy controls in Southwest Chinese Han population. Methods 259 HIV infected progressors,46 HIV infected long-term non-progressors and 270 healthy controls in Chinese Southwest Han population were enrolled in this study. Sequence specific primer( PCR-SSP) was used to genotype the-35 kb C / T polymorphism in these three groups. Results The distribution of-35 kb C / T polymorphisms in different groups were as expected from the HardyWeinberg equilibrium. In HIV infected progressors, the frequencies of CC,CT,TT were 15. 1%,41. 3%,43. 6% respectively; in HIV infected long-term non-progressors,the frequencies of CC,CT,TT were 21. 7%,39. 1%,39. 1% respectively; In healthy controls,the frequencies of CC,CT,TT were18. 9%,43. 0%,40. 4% respectively. These genotypes showed no statistically significant difference among HIV-infected progressors and HIV infected long-term non-progressors or healthy controls. Conclusion The-35 kb C / T polymorphism has no inheritance effect on HIV infection.
【Fund】: 科技部科研院所技术开发研究专项基金(2014EG150133);; 自然科学基金资助(NSFC 81001341)
【CateGory Index】: R512.91
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