Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Blood Transfusion》 2016-01
Add to Favorite Get Latest Update

Safety evaluation on human coagulation factor Ⅷ

MU Lei;LU Tao;WANG Qianchuan;LI Wei;YU Wei;Rongsheng Pharmaceutical Co. ,Ltd.;  
Objective To evaluate the safety of a plasma derived human coagulation factor Ⅷ( FⅧ). Methods Abnormal toxicity test were performed on rat guinea pig according to Chinese Pharmacopoeia. Hemolysis test of rabbit erythrocyte was performed by tube method in vitro. Rabbit vascular irritation test was performed by self-control method. The toxicity of the reagent residues was analyzed. Results No abnormal toxicity,no hemolysis reaction,no irritant reaction were found in the above tests. All the reagent residues were in safe ranges. Conclusion According to the results of pharmacological,toxicological test and the virus safety test,this FⅧ product is safety for clinical use.
【CateGory Index】: R965
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved