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《Chinese Journal of Blood Transfusion》 2016-04
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The influence of sodium pentobarbital intravenous anesthesia on the hemorheology and blood gas in Beagles

ZHAO Jingxiang;WANG Bo;YOU Guoxing;WANG Quan;SUN Zhenwei;ZHAO Lian;ZHOU Hong;Institute of Transfusion Medicine,Academy of Military Medical Sciences;  
Objective To investigate the influence of sodium pentobarbital intravenous anesthesia on hemorheological parameters and venous blood gas in beagles. Methods Blood samples from beagles( n = 30),in awake and anesthetized status,were collected from the cephalic vein and were used for hemorheological parameters and venous blood gas detection.Results After intravenous sodium pentobarbital anesthesia,the changes of the parameters were compared with waking state and were as followed: peripheral blood hemoglobin concentration( Hb) were( 16. 31 ± 1. 07 vs 13. 13 ± 0. 94),red blood cell hematocrit( Hct) were( 49. 99 ± 3. 27 vs 40. 25 ± 2. 88)( P 0. 01). The viscosity of whole blood decreased significantly from 7. 11 ± 0. 88 to 5. 03 ± 1. 39 at a shearing force of 10 s- 1,from 4. 47 ± 0. 42 to 3. 50 ± 0. 53,and from 3. 73 ±0. 36 to 2. 92 ± 0. 33 at a shearing force of 50 s- 1( P 0. 01). While after anesthesia,erythrocyte aggregation index decreased prominently( 47. 72 ± 2. 20 vs 43. 18 ± 3. 23)( P 0. 01). Also,the erythrocyte aggregation time was prolonged( 0. 272 ± 0. 034 vs 0. 430 ± 0. 124)( P 0. 01). In addition,when comparing with pre anesthesia status,the venous blood lactate concentration( Lac) decreased prominently after anesthesia( 1. 46 ± 0. 56 vs 1. 03 ± 0. 44)( P 0. 01). The partial venous oxygen pressure( Pv O2)( 48. 69 ± 8. 45 vs 55. 39 ± 8. 16) and oxygen saturation( Sv O2) increased significantly( 84. 56 ± 7. 00 vs 90. 53 ± 3. 46)( P 0. 01). Conclusion Sodium pentobarbital intravenous anesthesia could somewhat improve the blood perfusion in beagles.
【Fund】: 北京市科委首都市民健康培育项目(Z121100005312014)
【CateGory Index】: R614
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【Citations】
Chinese Journal Full-text Database 6 Hits
1 YOU Guoxing,WANG Ying,WANG Bo,YIN Yujing,ZHAO Lian,ZHOU Hong.Equally.Institute of Transfusion Medicine,Academy of Military Medical Sciences,Beijing 100850,China;The influence of different anesthesia on the physiology,blood gas and hemorheology of rat[J];中国输血杂志;2013-05
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHAO Jingxiang;WANG Bo;YOU Guoxing;WANG Quan;SUN Zhenwei;ZHAO Lian;ZHOU Hong;Institute of Transfusion Medicine,Academy of Military Medical Sciences;;The influence of sodium pentobarbital intravenous anesthesia on the hemorheology and blood gas in Beagles[J];中国输血杂志;2016-04
2 LIU Keliang;ZHENG Hua;GAO Jun;XIE Huiping;JIANG Yong;GE Yujie;WANG Rui;Sichuan Center for Disease Prevention and Control;;Difference of Two Blood Collecting Methods on Blood Biochemical Indicators and Blood Routine Test of SD Rats[J];预防医学情报杂志;2016-04
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7 ZHANG Jie;ZHANG Huan;DU Min;ZHANG Jing-jing;PENG Hai-feng;Department of General Surgery,Longgang Central Hospital of Shenzhen;Daprtment of General Surgery,Longgang District People's Hospital of Shenzhen;;Experiment Research on Duodenum-jejunal Bypass Surgery to Type 2 Diabetes Mellitus Rats[J];中国现代手术学杂志;2014-03
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