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《Chinese Journal of Blood Transfusion》 2016-04
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Case report: analysis on the efficaciousness of HAG chemotherapy on treating paroxysmal nocturnal hemoglobinuria

CHENG Xiaomin;MA Liangliang;JIANG Nengang;LI Jian;NIU Ting;LIU Ting;JIA Yongqian;Departmentof Hematology and Laboratory,Western China Hospital,Sichuan University;Center of Laboratory Science and Microbiology.Western China Hospital,Sichuan University;  
Objective To explore efficacious therapeuticplans for refractory paroxysmal nocturnal hemoglobinuria( PNH). Methods One patient with refractory PNH received two courses of HAG( Harringtonine 2mg / d d1- 7; Cytarabine 12. 5 mg /12 hours d1- 10; G-CSF 0. 3 mg / d d0- 10). Results Patient's symptoms gradually eased and her hemoglobin level maintained at 110- 120 g / dl for twelve months without transfusions. Her CD55 and CD59 negative erythrocytes decreased from 46. 8% to 25. 3%,and 51. 9% to 23. 7%,respectively.Her CD55 and CD59 negative granulocytes decreased from 80. 2% to 59. 7%,and 70. 3% to 32. 2%,respectively. She tolerated well during the chemotherapy. Conclusion HAG chemotherapy may be an alternative choice for those patient with prednisone resistance when allogeneic hematopoietic stem cell transplantation and eculizumab are unavailable.
【CateGory Index】: R556.64
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 CHEN AiLi;YANG JingYi;HU ShaoYan;WANG Qian-Fei;Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences;The Children's Hospital of Soochow University;;The priming induction regimen of HAG as a low dose chemotherapy strategy in AML clonal evolution[J];Science China(Life Sciences);2015-12
2 CAO Yan-ran, SHAO Zong-hong, JIA Hai-rong, SUN Juan, LIU Hong, WU Yu-hong, QIN Tie-jun, SHI Jun, BAI Jie, HE Guang-sheng, FU Rong, ZHAO Ming-feng, TU Hai-feng, CUI Zhen-zhu, YANG Tian-ying. Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China;Preliminary study of DA or HA regimen chemotherapy for the treatment of refractory and relapsed paroxysmal nocturnal hemoglobinuria[J];中华血液学杂志;2004-04
3 Shao Zonghong, Zhao Mingfeng, Li Ke, et al Institute of Hematology and Blood Diseases Hospital,CAMS and PUMC,Tianjin 300020;Outcome of low dose combined chemotherapy in refractory and relapsed paroxysmal nocturnal hemoglobinuria patients[J];中国实用内科杂志;2000-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 CHENG Xiaomin;MA Liangliang;JIANG Nengang;LI Jian;NIU Ting;LIU Ting;JIA Yongqian;Departmentof Hematology and Laboratory,Western China Hospital,Sichuan University;Center of Laboratory Science and Microbiology.Western China Hospital,Sichuan University;;Case report: analysis on the efficaciousness of HAG chemotherapy on treating paroxysmal nocturnal hemoglobinuria[J];中国输血杂志;2016-04
2 ;A case of refractory and recurrent AA-PNH syndrome treated with low-dose HA regimen and literature review[J];临床血液学杂志;2015-06
3 YUE Lan-zhu and SHAO Zong-hong Department of Hematology,General Hospital of Tianjin Medical University,Tianjin 300052,China;Research progress on the red cell diseases in China[J];Chinese Medical Journal;2012-15
4 FU Rong.Tianjin Medical University General Hospital,Tianjin 300052,China;The modern diagnosis and treatment of paroxysmal nocturnal hemoglobinuria[J];中国实用内科杂志;2012-05
5 DING Shao-xue,FU Rong,WANG Hong-lei,ZHANG Tian,RUAN Er-bao,QU Wen,LIANG Yong,WANG Guo-jin, WANG Xiao-ming,LIU Hong,WU Yu-hong,SONG Jia,WANG Hua-quan,XING Li-min,GUAN Jing, WANG Jun,LI Li-juan,SHAO Zong-hong.Department of Hematology & Oncology,Tianjin Medical University General Hospital,Tianjin 300052,China;Expression of phosphorylated STAT5 in bone marrow hematopoietic stem cells of patients with paroxysmal nocturnal hemoglobinuria before and after in vitro G-CSF or SCF stimulation[J];中华医学杂志;2012-14
6 WANG Dan,FU Rong,RUAN Er-bao,QU Wen,LIANG Yong,WANG Hua-quan,WANG Jun,LI Li-juan,LIU Hui,WANG Hong-lei,ZHANG Tian,LIU Hong,WU Yu-hong,XING Li-min,WANG Guo-jin,WANG Xiao-ming,SONG Jia,GUAN Jing,SHAO Zong-hong.Department of Hematology and Oncology,Tianjin Medical University General Hospital,Tianjin 300052,China;EPOR and TPOR expressions on CD34~+ CD59~- and CD34~+ CD59~+ bone marrow cells from patients with paroxysmal nocturnal hemoglobinuria[J];中华血液学杂志;2011-08
7 FU Rong.Department of Clinical Hematology & Oncology,General Hospital,Tianjin Medical University,Tianjin 300052,China;The diagnosis and treatment of acquired hemolytic anemia[J];中国实用内科杂志;2009-07
8 SHAO Zong-hong(Department of Hematology and Oncology,General Hospital,Tianjin Medical University,Tianjin 300052,China);Studies on aplastic anemia in China[J];基础医学与临床;2007-03
9 CAO Yan-ran, SHAO Zong-hong, JIA Hai-rong, SUN Juan, LIU Hong, WU Yu-hong, QIN Tie-jun, SHI Jun, BAI Jie, HE Guang-sheng, FU Rong, ZHAO Ming-feng, TU Hai-feng, CUI Zhen-zhu, YANG Tian-ying. Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China;Preliminary study of DA or HA regimen chemotherapy for the treatment of refractory and relapsed paroxysmal nocturnal hemoglobinuria[J];中华血液学杂志;2004-04
10 WANG Dan,FU Rang,RUAN Er-bao,QU Wen,LIANG Yong,WANG Hua-quan,WANG Jun,LI Li-juan,LIU Hui,WANG Hong-lei,ZHANG Tian,LIU Hong,WU Yu-hong,XING Li-min,WANG Guo-jin,WANG Xiao-ming,SONG Jia,GUAN Jing,SHAO Zong-hong.Department of Hematology & Oncology,Tianjin Medical University General Hospital,Tianjin 300052,China;STAT5 phosphorylation levels of erythropoietin and thrombopoietin receptors in CD34 ~+ CD59~- and CD34~+ CD59~+ bone marrow cells of patients with paroxysmal nocturnal hemoglobinuria[J];中华医学杂志;2011-30
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Shao Zonghong, Zhao Mingfeng, Li Ke, et al Institute of Hematology and Blood Diseases Hospital,CAMS and PUMC,Tianjin 300020;Outcome of low dose combined chemotherapy in refractory and relapsed paroxysmal nocturnal hemoglobinuria patients[J];中国实用内科杂志;2000-10
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