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《Chinese Journal of Blood Transfusion》 2016-04
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Analysis of low titer irregular antibody and invalid red blood cell transfusion

LI Haiyun;DING Yanjie;XU Xuexin;YANG Xun;Nanyang Central Blood Station;Nanyang Central Hospital;  
Objective To investigate red blood cell transfusion cases among patients in Nanyang,to select invalid infusion cases,and to analyze the correlation between invalid erythrocyte infusion and low titer irregular antibodies. Methods570 cases of patients with invalid transfusion were selected in the Central Hospital. Their blood samples were analyzed by serological test to detect the presence of low titer irregular antibodies. Results Among 570 patients with invalid red blood cell transfusion( 12. 5%),the ratio of female: male is obtained: χ2= 36. 81,P 0. 01,indicating a significant difference. A comparison on patients with history of blood transfusion and no history of blood transfusion was delineated below: χ2= 619. 6,P 0. 01,indicating a significant difference. A comparison on patients with history of pregnancy and no pregnancy was delineated below: χ2= 85. 5,P 0. 01,indicating a significant difference. 71 cases of invalid infusion caused by low titer irregular antibody accounted for 12. 4% of the total invalid red blood cell transfusion cases. Conclusion In Nanyang,invalid blood transfusion in patients is closely related to low titer irregular antibodies. Low titer irregular antibody is correlated with a history of blood transfusion,pregnancy,number of blood transfusion and the number of pregnancy. Conventional Polybrene method can be easily used to detect low titer irregular antibodies. Using low titer of the positive control reagents as control and a combination of modified Polybrene method and antiglobulin method can improve the detection rate,which can help to avoid ineffective detection of irregular antibodies and invalid transfusion.
【CateGory Index】: R457.1
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Chinese Journal Full-text Database 1 Hits
1 GUO Changyi;SONG Xuedong;SONG Renhao;The Fourth People's Hospital of Langfang City;Hebei Blood Center;;Detection threshold of 5 kinds of irregular antibody screening method[J];临床血液学杂志(输血与检验);2014-06
Chinese Journal Full-text Database 2 Hits
1 LI Haiyun;DING Yanjie;XU Xuexin;YANG Xun;Nanyang Central Blood Station;Nanyang Central Hospital;;Analysis of low titer irregular antibody and invalid red blood cell transfusion[J];中国输血杂志;2016-04
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