Animal models with transfusion-related acute lung injury
HU Ai;CHEN Weiyun;HUANG Yuguang;Department of Anesthesiology,Peking Union Medical College;
Transfusion-related acute lung injury( TRALI) is defined clinically as acute lung injury following transfusion of blood products within six hours,which is characterized by the acute onset of non-cardiogenic pulmonary edema and hypoxemia.TRALI is a serious complication of blood transfusion with high rates of morbidity and mortality,and has been one of the leading causes of transfusion-related death. However,the pathogenesis of TRALI has not yet been fully elucidated. Investigators explore the pathogenesis of TRALI mainly through the animal models. The relevant animal models have achieved gradual improvement. In this review,we will discuss the current status of the known experimental models of TRALI,further explore the pathogenesis of TRALI and provide design ideas for investigators to develop novel animal models.