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《Chinese Journal of Blood Transfusion》 2018-03
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Analysis of ordinary frozen plasma and virus-free plasma for plasma exchange therapy in the treatment of acute-onchronic liver failure

LI Huan;YANG Junlong;ZHENG Yinglong;HE Zhewen;PENG Dan;XIE Jia;XIAO Jie;Department of Blood Transfusion,The General Hospital of Chengdu Military;Clinical laboratory,the Second Chinese Medicine Hospital in Sichuan Province;Department of Clinical Laboratory,Sichuan Provincial Maternal and Children Health Hospital;  
Objective To analyze the clinical efficacy of ordinary frozen plasma and virus-free plasma in the treatment of acute-on-chronic liver failure and to evaluate the effectiveness and safety level of virus-free plasma in plasma exchange.Methods Retrospective data from patients with acute-on-chronic liver failure receiving the exchange therapy from January2015 to October 2015 was acquired and divided into two groups based on plasma types: the ordinary frozen plasma group and the virus-free plasma group. We observed the white blood cells level,blood coagulation indexes and other biochemical indicators in the two groups before and after the plasma exchange. The efficiency and mortality after treatment were also investigated. Results The common frozen plasma group pre and post treatment: WBC( × 109/L) 7. 85 ± 3. 51 vs 11. 04 ± 7. 29( P 0. 01),Biochemical indexes: TBIL( μmol/L) 364. 37±115. 31 vs 233. 11±102. 67( P0. 01); Abl( g/L) 32. 12± 4. 25 vs30. 22±3. 73( P0. 01); ALT( U/L) 273. 73 ± 360. 46 vs 117. 70 ± 136. 60( P 0. 01); AST( U/L) 258. 04 ± 336. 85 vs117. 90±99. 07( P0. 01); Blood coagulation indexes: PT( s) 18. 71±6. 43 vs 17. 21±6. 17( P0. 05); APTT( s) 46. 51±15. 27 vs 46. 64±14. 00( P0. 05); FIB( g/L) 1. 68±0. 84 vs 1. 42±0. 78( P0. 05); The virus-free plasma group pre and post treatment: WBC( × 109/L) 6. 37 ± 2. 19 vs 7. 66 ± 3. 74( P 0. 05),Biochemical indexes: TBIL( μmol/L) 331. 70 ±127. 44 vs 224. 91±75. 87( P0. 01); Abl( g/L) 32. 47±2. 48 vs 29. 75±2. 53( P0. 01); ALT( U/L) 524. 45±398. 71 vs177. 47±156. 48( P0. 01); AST( U/L) 324. 79±333. 49 vs 123. 00±96. 97( P0. 01). Blood coagulation indexes: PT( s)16. 90±5. 54 vs 17. 29±2. 44( P 0. 05); APTT( s) 47. 63± 15. 29 vs 50. 91± 9. 96( P 0. 05); FIB( g/L) 1. 73± 1. 53 vs1. 73±1. 53( P0. 05). There is no significant difference in the improvement rates of the two groups post treatment( P 0. 05).Conclusion There is no difference in the curative effect of ordinary frozen plasma and virus-free plasma for the treatment of acute-on-chronic liver failure. However,it is recommended to use virus-free plasma for safety concerns.
【CateGory Index】: R457.1;R575.3
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