Meta-analysis of the prognostic effects of allogeneic transfusion on patients withmalignant tumor
LIU Zhijie;WANG Wenxuan;LI Xiaoping;YUAN Xuewen;LI Hongxia;YANG Hongjun;Department of Blood Transfusion,Affiliated Hospital of North Sichuan Medical College;Department of Radiology,Nanchong Central Hospital;
Objective To evaluate the effect of allogeneic blood transfusion( ABT) on the prognosis of patients with malignant tumor. Methods We searched Pub Med,CENTRAL,EMbase,ISI Web of Knowledge Databases,VIP,CNKI,CBM and Wanfang database for all the literature comparing allogeneic blood transfusions and autologous or non-transfused malignancies. For the construction of the library until June 30,2017,at the same time hand-checked into the literature reference. According to the exclusion criteria,the two men independently conducted the screening of the literature,data extraction and quality evaluation,using the Stata 12. 0 meta-analysis. Results Finally included 18 studies,a total of 8158 patients.The results of Mata analysis showed that the effect of ABT on the recurrence rate and short-term survival( ≤5 years) in patients with malignant tumor was RR = 1. 48( 95% CI: 1. 06—2. 06),P0. 05 and RR = 1. 22 ∶1. 03—1. 44),P0. 05,the difference was statistically significant,but the long-term survival rate( 6 ~ 20 years),disease-free survival rate and tumorspecific survival rate were not statistically significant. Conclusion The available evidence suggests that ABT can promote the recurrence of malignant tumors and reduce the short-term survival rate,clinicians should be cautious about transfusions of patients with malignant tumors.
【CateGory Index】： R457.1;R730.7