Viral metagenomics and blood safety
FENG Bo;CHEN Li;QIU Yan;Beijing Red Cross Blood Center;
The characterization of the human blood-associated viral community( also called blood virome) is essential for epidemiological surveillance and prediction of potential threats to blood transfusion safety. Currently,the risk of bloodborne agent of well-known virus( HBV,HCV and HIV) is strictly monitored nationwide. Nevertheless,Unknown or unexpected virus may still infect recipients by blood-derived products.This is particularly relevant considering the fact that a significant proportion of transfusion-treated patients are immune-compromised and thus are more frequently subjected to fatal outcomes.Several measures to prevent the transfusion-transmitted unknown virus have been implemented in blood banks,including the exclusion of at-risk donors,leukocyte reduction of the donor blood and physicochemical treatment for different blood components. Unfortunately,there is no universal method for pathogen inactivation for now,which would be applicable for all types of blood components and equally effective for all viral families. In addition,among available inactivation procedures of viral genomes,some are recognized to be less effective on non-enveloped viruses and inadequate to inactivate higher viral titers in plasma pools or derivatives. Given such concerns,there is a rising need to invent new methodologies for the discovery of unknown viruses that may affect blood transfusion. Viral metagenomics combined with high throughput sequencing may be a promising approach for the identification and global surveillance of new and/or unexpected viruses that could impair blood transfusion safety.
【CateGory Index】： R457.1