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《Chinese Journal of Blood Transfusion》 2019-01
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The role of Th9、Th17、CD4~+CD25~+FoxP3~+ regulatory T cells in the peripheral blood of patients with chronic lymphocytic leukemia

GAO Yong;SONG Yue;HAN Shukun;BI Xiaolin;Blood Immunology Laboratory,Dalian Blood Center;Dalian Centers for Disease Control and Prevention;  
Objective To investigate the presence and significance of Th9,Thl7,T regulation cells and the related cytokines(IL-9、IL-17 、TGF-β) in the peripheral blood of patients with adult Chronic Lymphocytic Leukemia. Methods The peripheral blood samples were obtained from 36 CLL patients in the Second Hospital of Dalian Medical University(Dalian, China), including 10 females and 26 males; mean of age, 61±9 years. The control samples were collected from 45 healthy volunteers(13 females,32 males; mean age, 57±11 years), none of which suffered from any immune diseases. The percentages of Th9,Th17 and Treg cells in the samples were detected by Flow cytometry.The serum levels of IL-9,IL-17 and TGF-β were examined by ELISA. Data analysis was carried out using SPSS 18.0 statistical software. Descriptive data was summarized and analyzed.Results Compared with the control, the percentages of Th9,Thl7 and concentrations of IL-9,IL-17 were all significantly increased in patients with CLL[(1.29±0.35)% vs.(0.74±0.23)%, P0.05;(2.15±0.46)% vs.(1.08±0.37)%, P0.05;(24.25±7.05)% vs.(16.35±5.42)%, P0.05;(11.47±3.99)% vs.(7.36±2.85%), P0.05];the percentages of CD4~+CD25~+FoxP3~+ cells and concentrations of TGF-β were lower in the patient group [(4.76±0.89)% vs.(7.26±1.95)%,P0.05;(3.82±1.39)% vs.(6.82±2.01)%,P0.05]. Moreover, the percentages of Th9,Thl7 and concentrations of IL-9,IL-17 were all negatively correlated with lymphocytic accounts(γ_s=-0.374, P=0.034;γ_s=-0.382,P=0.032;γ_s=-0.445,P=0.011;γ_s=-0.413,P=0.024) of the patients with CLL; the percentages of CD4+CD25+FoxP3+ cells and concentrations of TGF-β were positively correlated with the lymphocytic accounts(γ_s=0.416,P=0.023;γ_s=0.403,P=0.028) of the patients with CLL. Conclusion The abnormality Th9,Thl7 and Treg cells and their related cytokines(IL-9, IL-17 and TGF-β) changes in patients with CLL,which may contribute in the immunological pathogenesis of CLL.
【CateGory Index】: R733.72
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