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ENGLISH OF ORIGINAL ARTICLES ( Study on Length Polymorphology of Enlarging Fragment at Apo B 3 Locus in Population Cohort of Han Nationality in Chengdu Region )

Jing Qiang,et al (West China University of Medical Sciences)  
The length polymorphology analysis of enlarging fragment at Apo 3 locus in 200 unrelated patients out of population cohort of Han nationality in Chengdu region has been performed,using the technique of analysing the length polymorphology of enlarging fragment.As a result,sixteen alleles have been found,with their fragment sizes ranging between 542 and 992 bp,gene frequencies of 0.0025~0.3750,heterozygosity of 0.79 and DP value of 0.95.Of 138 possible genotypes,43 genotypes have been found.The observed and expected values of those genotypes coincide with the Hardy Weinberg equilibrium( χ 2=2,13,df=1.0,P 0.01).The family line investigation showed that the inheritance of Apo B 3 locus follows the Mendelian Law.The sensetivity and specificity of the technique can be improved with HS PCR method.
【Fund】: 卫生部科研基金
【CateGory Index】: Q347
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