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Study on Thrombogenicity of Prothrombin Complex Concentrate Post Inactivation of Virus by S/D in Non stasis Canine Model

Du Junrong,et al (Institute of Blood Transfusion,Chinese Academy of Medical Sciences and Peking Union Medical College)  
To evaluate further the potential thrombogenicity of the prothrombin complex concentrate(PCC) produced by new technological process with virus inactivation by S/D technique.Method:The experimental study was carried out in non stasis canine model,meanwhile the dynamic monitoring of the following seven indices was performed:platelete count(determinated immediately),D dimer,thromboxane B 2(TXB 2),factor V activity,factor Ⅷ activity,protein C activity and partial thromboplastin time(PT),and the new prothrombin complex concentrate was compared with the old one produced by technological process without virus inactivation treatment by S/D in respect of potential thrombogenicity.Results:The potential thrombogenic tendency of new prothrombin complex concentrate showed by dynamic changes of their indices mentioned above was obviously better than that of the old one.Conclusion:The new prothrombin complex concentrate not only has higher safety in terms of virus infection,but also has obviously lower risk of thrombogenicity.
【Fund】: 中国医学科学院中国协和医科大学科研基金
【CateGory Index】: R457
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1 ZHOU Min;ZENG Ren-yong;LIU Yuan-yuan;LI Chang-qing;CAO Hai-jun;HE Ze-chao;College of Chemical Engineering,Sichuan University;Institute of Blood Transfusion,Chinese Academy of Medical Science;;Preparation technology of new gel-purified prothrombin complexes concentrates[J];中国生化药物杂志;2016-11
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