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《CHINESE JOURNAL OF BLOOD TRANSFUSION》 1999-01
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Study on Thrombogenicity of Prothrombin Complex Concentrate Post Inactivation of Virus by S/D in Non stasis Canine Model

Du Junrong,et al (Institute of Blood Transfusion,Chinese Academy of Medical Sciences and Peking Union Medical College)  
To evaluate further the potential thrombogenicity of the prothrombin complex concentrate(PCC) produced by new technological process with virus inactivation by S/D technique.Method:The experimental study was carried out in non stasis canine model,meanwhile the dynamic monitoring of the following seven indices was performed:platelete count(determinated immediately),D dimer,thromboxane B 2(TXB 2),factor V activity,factor Ⅷ activity,protein C activity and partial thromboplastin time(PT),and the new prothrombin complex concentrate was compared with the old one produced by technological process without virus inactivation treatment by S/D in respect of potential thrombogenicity.Results:The potential thrombogenic tendency of new prothrombin complex concentrate showed by dynamic changes of their indices mentioned above was obviously better than that of the old one.Conclusion:The new prothrombin complex concentrate not only has higher safety in terms of virus infection,but also has obviously lower risk of thrombogenicity.
【Fund】: 中国医学科学院中国协和医科大学科研基金
【CateGory Index】: R457
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Yu Rong; Yuan Ye; Xiao Xiaopu et al (Institule of Blood Tranfusion, Chinese Academy of Medical Sciences, Peking Union Medical College, Chengdu 610081 );Study on Characteristics of A Newtype Prothrombin Complex Concentrate After the Virus Inactivation by S/D Method[J];中国生物制品学杂志;1997-03
2 ;ENGLISH AbstractS OF ORIGINAL ARTICLES Prothrombin Complex Concentrate Prepared by Modified GelAdsorption Method[J];中国输血杂志;1997-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHOU Min;ZENG Ren-yong;LIU Yuan-yuan;LI Chang-qing;CAO Hai-jun;HE Ze-chao;College of Chemical Engineering,Sichuan University;Institute of Blood Transfusion,Chinese Academy of Medical Science;;Preparation technology of new gel-purified prothrombin complexes concentrates[J];中国生化药物杂志;2016-11
2 CAO Haijun1,WANG Zongkui1,HU Jijun2,WANG Yumei2,YE Shengliang1,DU Xi1,ZHANG Xuejun1,YUAN Jing2,LIN Fangzhao1,LI Changqing1.1.Institute of Blood Transfusion,Chinese Academy of Medical Sciences & Peking Union Medical College,Chengdu 610052,China;2.Guizhou Taibang Biological Products Co.Ltd.;Effect of different adsorption system on the coagulation inhibitors in prothrombin complex concentrate[J];中国输血杂志;2012-12
3 CHAO Haijun,DU Xi,YE Shengliang,ZHANG Xuejun,WANG Zongkui,Lin Fangzhao.LI Changqin.Institute of Blood Transfusion,Peking Union Medical College&Chinese Academy of Medical Sciences,Chengdu 610052,China;Studies of adsorption conditions in prothrombin complex concehtrates production[J];中国输血杂志;2012-07
4 XIONG Ying~1,ZHAO Hong-wei~1,XU Qi~1,HE Qi~2,FANG Wei-mao~(1*) (1.School of Chemical Engineering,Sichuan University,Chengdu 610065; 2.Chenguang Research Institute of Chemical Industry,China National Blue Star Co.,Chengdu 610041);Separation of Prothrombin Complex Concentrates from Plasma by Macroporous Anion-Exchange Resin[J];中国医药工业杂志;2009-05
5 LIU Xin-yan1,2,WANG Feng-shan1,ZHONG Li-jun2,GUO Shu-ying3,FENG Wei-guo2,SHI Xiu-mei2,LI Rong-zhen2(1.Institute of Biochemical and Biotechnological Drug,School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;2.Institute of Biological Products of Shandong Province,Tai′an 271000,China;3.88th Hospital of People′s Liberation Army of China,Tai′an 271000,China);Preparation procedure of human prothrombin complex concentrate by a two-step gel adsorption chromatography process[J];中国生化药物杂志;2008-01
6 CHEN Gang1 QIU Jiashan1 ZHAO Hongwei1 FANG Weimao1 HE Qi2 XU Qi1 ZHONG Benhe1 TANG Jing1 1 Sichuan University School of Chemical engineering, Chengdu 610065 2 Chenguang Research Institute of Chemical Industry, China National Blue Star Co. Chengdu 610041;RESEARCH AND ANALYSE ON ADSORPTION BEHAVIOR FOR PROTHROMBIN COMPLEX CONCENTRATE ON NOVEL ANION EXCHANGER CG-6[J];离子交换与吸附;2007-02
7 YU Rong 1* , LI Xiao hong 1, QI Hui 1 ,WU Yang bin 2, ZENG Rong 1(1.West China School of Pharmacy, Sichuan University, Chengdu, 610041,China;2.Ningbo Asia Pacific Biotechnology Ltd, Ningbo,315803,China );A batch procedure for preparation of factor Ⅸ complex concentrates[J];中国现代应用药学;2003-06
8 Zeng Rong *, Yu Rong, Li Xiaohong, Wu Yangbin,Qi Hui. *Department of Biopharmaceutics,West China School of Pharmacy, Sichuan University, Chengdu 610041, China;Technology Optimization and Properties Study of Factor Ⅸ Complex Concentrates[J];四川大学学报(医学版);2003-01
9 LI Xiao-hong, YU Rong, WU Yang-binWest China School of Pharmarcy, Sichuan University, Chengdu 610041 Ningbo Ya Tai Biological Techonology Co. Ltd. Ningbu 315803;Measurement of Activated Clotting Factors in the Factor Ⅸ Complex Concentrate and in Vitro Thrombogenicity Study[J];血栓与止血学;2001-04
10 Du Junrong,et al (Institute of Blood Transfusion,Chinese Academy of Medical Sciences and Peking Union Medical College);Study on Thrombogenicity of Prothrombin Complex Concentrate Post Inactivation of Virus by S/D in Non stasis Canine Model[J];中国输血杂志;1999-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Huang Jinming et al(Shanghai Institute of Biological Products, Shanghai);Virus Inactivation in Prothrombin Complex Concentrate[J];中国生物制品学杂志;1995-03
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