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Therapeutic effect of pilose antler polypeptides (PAP) on experimental fracture and its mechanism

Zhou Qiuli,Wang Lijuan *,Guo Yingjie,Wang Yan,Wang Ying, Liu Yongqiang,Li Bingjun,Wang Benxiang (Institute of Preclinical Sciences,NBUMS;*\ Research Centre of New Drug, Changchun College of Traditional Chinese Medicine,Changchun)  
Objective:To test the therapeutic effect of PAP on experimental fracture and its mechanism.Methods:Effect of PAP on the incorporation of 〔 3H〕 TdR into DNA syntheses in the cells of rabbits costal cartilage and human embryonic joint as well as osteoblast precursor cells of embryonic chick calvaria in vitro and effect of PAP on the experimental radius fracture in rats in vivo were observed.Results:PAP of 10~50 μg·ml -1 showed mitogenic activities and significant promotion of DNA syntheses for various cartilage cells in vitro.In vivo experimental results revealed that PAP 10 and 20 mg·kg -1 could promote healing of radius fracture,accelerate osteotylus formation and increase contents of calcium and oxyproline.Conclusion:PAP accelerates fracture healing through promoting multiplications of cartilage and osteoblast precursor cells,collagen accumulation and calcium precipitation in osteotylus.
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