Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Bethune Military Medical College》 2007-01
Add to Favorite Get Latest Update

Embryotoxicity of Cyclophosphamide in Mice

JIA Qingjun,ZHOU Yan hong, YANG Lujun,et al.Bethune military medical college, Shijiazhuang 050081,China  
Objective The embryotoxic effect of cyclophosphamide (CP) was studied. Methods 20 pregnant mice were randomly divided into two groups.Physiological saline was injected in control group,and CP (10 mg·kg -1 ·d -1 ) was injected in experimental group.The weight of pregnant mice,embryo mice and placenta was measured.The rates of death and absorption in mice fetuses were counted. Results After the mice given CP,the weight of pregnant mice,embryo mice and placenta was significantly reduced (P0.05).The numbers of absorbed and dead embryo were increased apparently(P0.01).Conclusion CP has embryotoxicity to mice.
【CateGory Index】: R114
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 YING Yong,HU Jian-ting,WANG Shao-yan,QU Hui-jin,LI Yan,WANG Feng-qian (Shandong Institute of Pharmaceutical Industry,Shandong Provincial Key Laboratory of Chemical Drugs,Jinan,Shandong,250033,China);Common Positive Control Agents in Teratogenicity Tests in Animals[J];Progress in Veterinary Medicine;2012-02
2 LUO Wenhai.Department of Hygienics,Yantai School Area of Binzhou Medical College,Shandong Province 264003;Effects of Cyclophosphamide on Reproductive Function of Rats[J];The Journal of Medical Theory and Practice;2011-06
【Citations】
Chinese Journal Full-text Database 4 Hits
1 Zhao Jingchun, Wang Lingshi Biology Department of Beijing Institute of Education, Beijing\ 100044;STUDY ON GENETIC AND REPRODUCTIVE TOXICITY OF SECOND HAND SMOKING IN MICE[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-05
2 Zhao Hong gang\+1, Chen Xian jun\+2, Gan Ya ping\+1 (1. Pathology Department of Xianning Medical College; 2. Biology Department of Xianning Medical College, Xianning 437100, China);EMBRYOTOXICITY OF SODIUM SELENITE IN MOUSE[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-02
3 Wei Min Δ, Fang Jixi (Department of Histology and Embryology, Suzhou Medical College, Suzhou);MALFORMED EFFECT OF TERBINAFINE ON THE MOUSE EMBRYOS[J];ACTA ANATOMICA SINICA;1999-02
4 Academy of Military Medicine, Institute of Microbiology and Epidemiology, Beijing 100071 Shi Xiao-Chun et al.;EMBRYOTOXICITY AND TERATOGENICITY OF AN ORGANOGALLIUM COMPOUND IN MICE[J];JOURNAL OF LABOUR MEDICINE;1997-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Xiu-ying, HU Yi-xiu, QIU Feng, HU Yu-ming, ZANG Xue-bing, ZHOU Yue-chan(Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China);STUDY ON THE GENOTOXICITY OF GANTAIKANG[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-02
2 XU Yi_ping, SONG Rui_kun, SHI Nian, et al.(Department of Health Toxicology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 , China);STUDY ON MUTAGENICITY OF CULTURED CALCULUS BOVIS[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-01
3 CONG Hong-qun,CHENG Han - yi,ZHONG Jin-yi (1. Medical College of Qingdao University, Qingdao 266021, China; 2.Railway Sanitation Supervision Bureau of Changchun, Changchun 130051, China,);Inhibitory Effect of Grape Procyanidin on the Mutagenicity of N-nitroso Compounds[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-01
4 YAO Yu_na,LIU Ping,WANG Shu_e,et al (Department of Chemistry and Microbacteria Detection,College of Public Health,Shandong University,Jinan250012,China);Study on Acute Toxicity of Mice and Micronucleus in Peripheral Blood and Spern Abnormality of Mice Induced by Marine[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-02
5 KAO Qing-jun,WU Kun ,LI Hong-wei,et al (1.Public Health college,Harbin Medical University,Harbin150001,China;2.The aquatic products institut of Heilongjiang province,Harbin150001,China);The Effect of Trivalent Chromium and Hexavalent Chromium on the Micronuclear Rate and the Sperm Abnormality of Mice[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-03
6 JIA Qing-jun, YANG Lu-jun, LIU Jin-yi, et al (Department of Hygienic Toxicology, Preventive Medicine College, Third Millitary Medical University, Chongqing 400038, China);Study on the Acute Toxicity and the Genetic Damage of Chromosome in Mice After Exposure to Hydroxylammonium Nitrate[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-06
7 JIA Qing-jun, YANG Lu-jun, LIU Jin-yi, et al (Department of Hygienic Toxicology, Preventive Medicine College, Third Millitary Medical University, Chongqing 400038, China);Effect on Testicular Germ Cell and Sperm in Mouse After Exposure to Hydroxylammonium Nitrate[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-06
8 JIA Qing-jun, ZHOU Yan-hong, LIU Jin-yi, et al (Department of Hygienic Toxicology, Preventive Medicine College, Third Millitary Medical University, Chongqing 400038, China);Embryotoxicity and Teratogenicity of Han in Mice[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-06
9 AN Hui, LIU Jin-yi, YANG Lu-jun, et al (Department of hygienic toxicology, Preventive Medicine College, Third Military Medical University, Chongqing, 400038, China);Effect of Exposure to Hydroxylammonium Nitrate on Micronucleus Frequency of Bone Marrow Cells in Wistar Rat for 90 Days[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-06
10 XIAO Kai,LI Hong-xia (National Chengdu Center for Safety Evaluation of Traditional Chinese Medicine,West China Hospital, Sichuan University,Chengdu610041,Sichuan,China);Effects of Cyclopho sphamide Dose and Sampling Time on Mouse Micronucleus Frequency in Bone Marrow[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-06
China Proceedings of conference Full-text Database 4 Hits
1 CAO Jian-ping,WANG Wen-xiang,LIAO Hui-zhen,et al.Department of Nutrition and Health Care,Institute of Public Health,Fujian Medical University.(Fuzhou 350004,China);Effects of Subchronic Cadmium Exposure on Male Reproductive Ability in Rats.[A];[C];2004
2 Chen Gui-hong (Xixiang People's Hospital,Baoan Distric,Shenzhen,518102) Huang Qing-song (Guangdong Pharmaceutical University,Guangdong,Guangzhou,510006) Zeng Fan-tao (Futian People's Hospital,Futian Distric,Shenzhen,518011);The study on the effect of Slaking cancer tablet on anti-mutation and anti-tumor[A];[C];2007
3 ZHAO Hai-jun~1,ZHANG Gui-ying~2,XIN Zhen-jiang~1,WANG Bao-gui~2,ZHANG Hui~2 (1.Zhejiang Medical College,Hangzhou 310053.China;2.Deptartment of Nutrition and Food Hygiene,School of Public Health,Jinlin University,Changchun 130021,China);Effect of cerium nitrate on the reproductive capacity of male mice[A];[C];2009
4 Zhuo Qin,Chen Xiaoping,Piao Jianhua,Han Chi,et al. Institute of Nutrition and Food Safety,Chinese Centre for Diease Control and Prevention,Beijing 100050,China;Study on the teratogenicity effects of genetically modified rice which expressed cowpea trypsin inhibitor on rats[A];[C];2004
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 zhang Xiaoling,Xiang Hua,Yuan Zhenhua The Department of Toxicology Hangzhou Hygiene and Anti-epidemic Station,Hangzhou 310006;STUDY ON THE TERATOGENIC EFFECTS oF CYCLOPHoSPHAMIDEWlTH VARLOUSORS DOSAGE SCHEDULES IN RATS[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1994-06
2 LI Dao-zhong1,PENG Dai-yin2,ZHANG Rui2,Xu Xian-xiang2(1.Department of Phar,Tongcheng People′s Hospital,Tongcheng Anhui,231400;2.Anhui College of Traditional Chinese Medicine,Anhui 230038);Effects of cuscuta chinensis polysaccharide on diabetic mice by alloxan[J];Anhui Medical and Pharmaceutical Journal;2008-10
3 JIA Qingjun~*,LIU Tianpeng,GUO Kuiliang,et al.~*Bethune military medical college,Shijiazhuang 050081,China;Effect on Testicular Germ Cell after Exposure to Cyclophosphamide in Mice[J];Journal of Bethune Military Medical College;2006-02
4 FEI Rui1,2,CHI Li-chao2,DU Jian-shi3,FU Jun-quan2,HE Yuan2,XING Shen-yang4(1.Institute of Genetics and Cytology,Northeast Normal University,Changchun 130024,China;2.School of Bethune Medical Science,Jilin University,Changchun 130021,China;3.China-Japan Union Hospital,Jilin University,Changchun 130033,China;4.College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062,China);Toxicity of polysaccharides of Boschniakia rossica[J];Journal of Northeast Normal University(Natural Science Edition);2008-02
5 YING Yong,HU Jian-ting,WANG Shao-yan,QU Hui-jin,LI Yan,WANG Feng-qian (Shandong Institute of Pharmaceutical Industry,Shandong Provincial Key Laboratory of Chemical Drugs,Jinan,Shandong,250033,China);Common Positive Control Agents in Teratogenicity Tests in Animals[J];Progress in Veterinary Medicine;2012-02
6 GAO Xue-yong, WANG Wei, HAN Mi-sha, LIN Shan, HE Wei-min. Department of Anatomy Histology and Embryology, Fujian Medical university, Fuzhou 350004 China;The effect of cyclophosphamide on the testis and epididymis of rat[J];Anatomy Research;2009-01
7 ZHAO Min,CHEN Bi-feng,YANG Xing-fen,et al. Center for Disease Control and Prevention of Guangdong Province,Guangzhou 510300,China;Study of the teratogenicity of acetylsalicylic acid in SD rats[J];South China Journal of Preventive Medicine;2009-04
8 Liu Danzhuo,You Zhaoling,Zhao Xinguang(Hunan University of TCM,Changsha 410007,China);Study on toxicity of Shoutai Pills for reproductive function and embryonic development in pregnant SD rats[J];Journal of Gansu College of Traditional Chinese Medicine;2008-06
9 Li Fengwen,Liu Rongzhen,Zhao Peng,et al. Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control(Nanning 530021);The exploration of the effect of cyclophosphampide on the spean deformity in the mice[J];Guangxi Medical Journal;2003-03
10 HE Dong-mei,LEI Lei Doctor in 2007 Grades of Hunan University of Traditional Chinese Medicine,Changsha,China,410007;Study Progress on the Treatment of Recurrent Abortion With Shoutai Pills[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2008-12
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Chen Xianjun, Zhao Honggang Biology Department and Pathology Department, Xianning Medical College, Hubei 437100;HIGH DOSE SELENTUM INDUCED SCE AND CHROMOSOME ABERRATION IN HUMAN LYPHOCYTES[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-02
2 XinHua,ShaoHonglian Departmeet of Biology,Shangdong Medical Universify,Jinan 250012;A SIMPLE METHOD PREPARING SAMPLE FOR OBSERVING MlCRONUCLEUS IN MALE REPRODUCTIVE CELL5[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1994-06
3 Liu Lingyun,Di Shaojie,Liu Yan,Fei Qing and Guo Xuecong;A SIMPLE NEW TECHNIQUE FOR IN VIVO DETECTION OF THE SCE IN MOUSE CELLS[J];Journal of Beijing Normal University(Natural Science);1985-04
4 Wu Desheng;Heng Zhengchang;Wang Guoqin;Dong Qinan Department of Environmental Health Research Unit of Hygienic Toxicology;DETECTION OF FETUS GROWTH RETARDATION IN TERATOGENIC STUDIES ON MICE Skeletal Development of Fetus in Perinatal Period[J];;1984-01
5 CHEN Xianjun,ZHAO Honggang,XU Aiqin Department of Biology,Xianning Medical College,Hubei 437100;Effects of sodium selenite on transformation and proliferation of human peripheral blood lymphocytes in culture in vitro[J];CHINESE JOURANL OF CNDEMIOLOGY;1999-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved