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《Journal of Bethune Military Medical College》 2007-01
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Embryotoxicity of Cyclophosphamide in Mice

JIA Qingjun,ZHOU Yan hong, YANG Lujun,et al.Bethune military medical college, Shijiazhuang 050081,China  
Objective The embryotoxic effect of cyclophosphamide (CP) was studied. Methods 20 pregnant mice were randomly divided into two groups.Physiological saline was injected in control group,and CP (10 mg·kg -1 ·d -1 ) was injected in experimental group.The weight of pregnant mice,embryo mice and placenta was measured.The rates of death and absorption in mice fetuses were counted. Results After the mice given CP,the weight of pregnant mice,embryo mice and placenta was significantly reduced (P0.05).The numbers of absorbed and dead embryo were increased apparently(P0.01).Conclusion CP has embryotoxicity to mice.
【CateGory Index】: R114
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