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《Journal of Bethune Military Medical College》 2008-01
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The Expresslon et NF-κB p65 and COX-2 in Laryngeal Carcinoma and Their Correlation with Clinical Signiflcance

WU Yanzhao~* XIONG Chen,SHI Huijing,et al.*Department of otolarynology,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China  
Objective To study the relafionship and expression of nuclear faetor-κB p65(NF-κB p65)and cyclooxygenase-2(COX-2)in hu- man Iaryngeal carcinoma.Methods The expressions of NF-κB p65 and COX-2 were examined by FCM in paraffin embedded cancerous and adjacent noncancerous tissue specimens of 50 laryngeal carcinoma and 20 normal laryngeal mucosa samples.Results The expressions of NF-κB p65 and COX-2 in laryngeal carcinoma were 1.20(FI)and 1.26(FI)respectively,hut the expressions in adjacent noncanecerous tissues were 1.03(FI) and 1.04(FI).Conclusion Overexpressions of NF-κB p65 and COX-2 may play an important role in the occurrence and development of laryngeal carcinoma.NF-κB p65 may enhance the expressian of COX-2.
【Fund】: 河北省普通高校肿瘤强势特色学科支助
【CateGory Index】: R739.6
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