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《Journal of Bethune Military Medical College》 2008-01
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The Preliminary Study on the Embryotoxic Effect of Diethylstilbestrol in Rats

WU Jing WU Yansen ZHAO Changyao.Department of Medicine,Changjiang University,Hubei 434000,China  
Objective To investigate the embryotoxic effect of diethylstilbestrol in rats.Methods The pregnant rats were treated with di- ethylstilbestrol via injection at concentrations d 50μg·kg~(-1)·d~(-1)or 100μg·kg~(-1)·d~(-1)throughout gestation.The general status of pregnant rats and fetus was observed,Results Expcsure to diethylstilbestrol,at a concentration d 50μg·kg~(-1)·d~(-1),resulted in significant reduction in mean body weight of fetus.At adoseof 100μg·kg~(-1)·d~(-1),average litter size,and body and tail length of fetus significantly decreased.Conclusion There existed some embryotoxicity of diethylstilbestrol to rats.
【CateGory Index】: R96
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 DENG Wang-dong~1,LU Shan-ming~2,JIANG Xue-wu~3(1 Department of Urology,The First Affiliated Hospital,Shantou University Medical College,Shantou 515041,China;2 Department of Pathology,The First Affiliated Hospital,Shantou University Medical College,Shantou 515041,China;3 Department of Pediatric Surgery,The Second Affiliated Hospital,Shantou University Medical College,Shantou 515041,China);Experience of Establishing Animal Model to Observe the Effect of Prenatal Exposure to Diethylstilbestrol on Gubernacular Development in Fetal Male Kunming Mice[J];Journal of Shantou University Medical College;2005-03
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 DENG Wang-dong,LU Shan-ming,JIANG Xue-wu.Department of Urology,the First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China;Influence of diethylstilbestrol on expressions of proliferating cell nuclear antigen and ACTIN in gubernaculum testis of fetal male mice[J];Journal of Chinese Physician;2006-06
2 DENG Wang-dong,LU Shan-ming,JIANG Xue-wu,CHEN Zhong-xian,LIN Han.Department of Urology,The First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China;Effects of environmental estrogens on testicular descent and expression of actin in gubernaculum testis of fetal male mice[J];The Journal of Practical Medicine;2006-11
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