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《Journal of Bethune Medical Science》 2014-03
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An efficacy and safety study on the quadruple therapy of peptic ulcer in children

KUANG Zhaofeng;CAI Xingsheng;OU Shaoyang;Department of Paediatrics,People’s Hospital of Jieyang;  
Objective To study the efficacy and safety of bismuth,omeprazole,amoxicillin,furazolidone quadruple therapy in the treatment of peptic ulcer in children. Methods Ninety cases of peptic ulcer patients chosen as the research objects were randomly divided into two groups( n = 45,each). The control group was given omeprazole,amoxicillin,and clarithromycin therapy. The observation group was treated with omeprazole,amoxicillin,bismuth,and furazolidone treatment. The curative effect and safety of two groups were observed. Results Ninety patients completed the treatment course and did not terminate the treatment because of adverse reactions. The total cure rate of the observation group was 95. 56%,higher than 82. 22 % of the control group( P 0. 05). Helicobacter pylori( Hp) eradication rate( 93. 33%) was higher than that of the control group( 73. 33%,P 0. 05). The adverse reaction rate of observation group was lower than that of the control group( P 0. 05). Conclusion Bismuth,omeprazole,amoxicillin,furazolidone quadruple therapy in treatment of peptic ulcer can effectively eradicate Hp with better curative effect and less adverse reactions.
【CateGory Index】: R573.1
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【Co-citations】
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1 HUANG Ye-ni,LIU Li(proof-reader),University of South China,Hengyang,Hunan,421001,China);Research Advances of Treatment on Helicobacter Pylori Infectious Disease[J];Progress in Modern Biomedicine;2012-17
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3 Fu Guohong;;Clinical Experience of Treating 85 Cases of Peptic Ulcer in Children[J];China Journal of Pharmaceutical Economics;2013-S2
4 WANG Minglin;Department of Gastroenterology,the Wuchang Hospital of Wuhan;;Relationship of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs with peptic ulcer pathogenesis[J];Chinese Journal of Gastroenterology and Hepatology;2013-12
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