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《Journal of Bethune Medical Science》 2014-03
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The clinical research of the treatment on meconium aspiration syndrome with pulmonary surfactant

YAO Shuhai;JIANG Shanglin;HUANG Xiaoxia;Department of Pediatrics,Maternal and Child Health Centre of Shantou;  
Objective To explore the clinical effect of pulmonary surfactant( PS) on the treatment of meconium aspiration syndrome( MAS). Methods Eighty-four children with MAS were randomly divided into two groups( n = 42,each). The control group was treated with mechanical ventilation and conventional therapy,based on which,the observation group was given additional pulmonary surfactant. Then,therapeutic effect of the two groups was compared. Results In the observation group,the cure rate was 95. 24%,higher than 80. 95% of control group( P 0. 05) and the hospitalization time was( 12. 09 ± 3. 11) d,shorter than( 17. 81 ± 4. 07) d of control group( P 0. 01). There was no significant difference between carbon dioxide partial pressures( P 0. 05),however 24 h after treatment,the carbon dioxide partial pressure of observation group was lower than that of the control group( P 0. 01) but oxygen partial pressure was higher( P 0. 01). Conclusion The treatment of mechanical ventilation combined with pulmonary surfactant is obviously effective to neonates with MAS and can improve blood gas of the patients.
【CateGory Index】: R722.1
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Chinese Journal Full-text Database 1 Hits
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