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《Journal of Bethune Medical Science》 2014-04
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Combined therapy of penciclovir with interferon α-1b in treatment of severe herpes zoster: effect and safety

CHEN Sihua;Department of Dermatology,the Second Affiliated Hospital of Guangzhou Medical University;  
Objective To investigate the curative effect and safety of the combination therapy of penciclovir with interferon α-1b in treatment of severe herpes zoster. Methods Seventy-four patients with severe herpes zoster were divided into the observation group( n = 37) and the control group( n = 37),and the control group was given penciclovir injection,and the observation group was given additional interferon α-1b muscle injection,and curative effect of the two groups were observed. Results Pain relief time,blister check time,lesions subsiding time and 50% skin crusting time of the observation group after treatment were significantly shorter than that of the control group( P 0. 01). After 15 d of treatment,the curative effect of the two groups showed no statistically significant difference( P 0. 05). No serious adverse drug reactions occurred during the medication. The incidence rate of neuralgia( PHN) of the observation group was 9. 09%,lower than 29. 03% of the control group( P 0. 05). Conclusion Penciclovir with interferon α-1b in treatment of severe herpes zoster is safe and effective and can significantly shorten the course of the disease and reduce the incidence rate of PHN.
【CateGory Index】: R752.12
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